Cost-effectiveness analysis of emtricitabine/tenofovir versus lamivudine/zidovudine, in combination with efavirenz, in antiretroviral-naive, HIV-1-infected patients

Abstract Objective: The aim of this study was to compare the cost per unit of effectiveness (successful treatment episode) of 2 highly active antiretroviral therapy combinations–emtricitabine/tenofovir DF + efavirenz (TVD + EFV) and lamivudine/zidovudine + efavirenz (COMB + EFV)–in antiretroviral-na...

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Bibliographic Details
Published in:Clinical therapeutics 2008-02, Vol.30 (2), p.372-381
Main Authors: Sánchez-de la Rosa, Rainel, MD, PhD, Herrera, Luis, MD, Moreno, Santiago, MD, PhD
Format: Article
Language:English
Subjects:
Adenine - analogs & derivatives
Adenine - economics
Adenine - therapeutic use
Anti-HIV Agents - economics
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active
Antiviral agents
Benzoxazines - economics
Benzoxazines - therapeutic use
Biological and medical sciences
cost analysis
Cost-Benefit Analysis
Decision Trees
Deoxycytidine - analogs & derivatives
Deoxycytidine - economics
Deoxycytidine - therapeutic use
Drug Costs
Emtricitabine
HAART
Health Care Costs
Health Resources - economics
Health Resources - utilization
HIV Infections - drug therapy
HIV Infections - economics
HIV Infections - virology
HIV-1
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Internal Medicine
Lamivudine - economics
Lamivudine - therapeutic use
Medical Education
Medical sciences
Models, Economic
nucleoside-analogue reverse transcriptase inhibitors
Organophosphonates - economics
Organophosphonates - therapeutic use
Pharmacology. Drug treatments
Reverse Transcriptase Inhibitors - economics
Reverse Transcriptase Inhibitors - therapeutic use
Tenofovir
Time Factors
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Zidovudine - economics
Zidovudine - therapeutic use
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Summary:Abstract Objective: The aim of this study was to compare the cost per unit of effectiveness (successful treatment episode) of 2 highly active antiretroviral therapy combinations–emtricitabine/tenofovir DF + efavirenz (TVD + EFV) and lamivudine/zidovudine + efavirenz (COMB + EFV)–in antiretroviral-naive, HIV-1-infected patients from the perspective of costs to society. Methods: This cost-effectiveness analysis was modeled using a decision tree that considered the therapeutic response (successful treatment episode, ie, HIV-1 RNA
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2008.02.009