Effects of sibutramine and orlistat on mood in obese and overweight subjects: A randomised study

Abstract Background and aim Intentional weight loss results in improvement in mood. Very few data exist regarding the effects of sibutramine on the mood of obese and overweight patients in general clinical samples. Moreover, no study has evaluated the effects of orlistat treatment on mood. The purpo...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2008-03, Vol.18 (3), p.207-210
Main Authors: Kiortsis, D.N, Tsouli, S, Filippatos, T.D, Konitsiotis, S, Elisaf, M.S
Format: Article
Language:English
Subjects:
Adult
Affect - drug effects
Analysis of Variance
Anti-Obesity Agents - therapeutic use
Appetite Depressants - therapeutic use
Body Mass Index
Cardiovascular
Cyclobutanes - therapeutic use
Depression
Diet, Reducing
Female
Humans
Lactones - therapeutic use
Middle Aged
Mood
Obesity - diet therapy
Obesity - drug therapy
Obesity - psychology
Orlistat
Overweight - diet therapy
Overweight - drug therapy
Overweight - psychology
Prospective Studies
Psychometrics
Sibutramine
Treatment Outcome
Weight loss
Weight Loss - drug effects
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Summary:Abstract Background and aim Intentional weight loss results in improvement in mood. Very few data exist regarding the effects of sibutramine on the mood of obese and overweight patients in general clinical samples. Moreover, no study has evaluated the effects of orlistat treatment on mood. The purpose of our study was to assess the effects of sibutramine and orlistat on mood in obese and overweight subjects. Methods and results Sixty obese and overweight women were divided into three groups. The first group ( n = 20) received a low-calorie diet and sibutramine 10 mg; the second group ( n = 20) received a low-calorie diet and orlistat 120 mg three times a day, and the third group received only the low-calorie diet. Conclusion A psychiatric assessment was performed with the Hamilton Depression Rating Scale (HAMD) before and after 3 months of treatment. In all the groups a statistically significant decrease in HAMD scores was observed. However, the decrease in the sibutramine group was greater compared to that observed in the two other groups ( P < 0.01). These results suggest that sibutramine treatment may improve mood more than diet alone or orlistat therapy in a general clinical sample of obese patients.
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2006.10.003