A highly selective method for 11 beta-OH protection of steroidal 11 beta, 17 alpha-diols

A highly selective method to protect the 11 beta-OH position of steroid (1) has been developed. This is achieved via double silyl protection of the 11 beta, 17 alpha-diol, followed by selective desilylation of the 17 alpha-OH under basic conditions without the need for a fluoride source.

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Bibliographic Details
Published in:Steroids 2008-05, Vol.73 (5), p.574-577
Main Authors: Glossop, Paul A, Hoogenraad, Marcel, Peakman, Torren M, Roberts, Dannielle F
Format: Article
Language:English
Subjects:
Steroids - chemical synthesis
Steroids - chemistry
Structure-Activity Relationship
Online Access:Get full text
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Description
Summary:A highly selective method to protect the 11 beta-OH position of steroid (1) has been developed. This is achieved via double silyl protection of the 11 beta, 17 alpha-diol, followed by selective desilylation of the 17 alpha-OH under basic conditions without the need for a fluoride source.
ISSN:0039-128X
DOI:10.1016/j.steroids.2008.01.016