The prognostic significance of COX-2 and survivin expression in ovarian cancer

We investigated the prognostic significance of cyclooxygenase-2 (COX-2) and survivin in ovarian carcinoma. Imprint smears were obtained from 100 ovarian carcinoma specimens and were studied immunocytochemically for the expression of COX-2 and survivin. The results were correlated with several clinic...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2008-01, Vol.204 (4), p.241-249
Main Authors: Athanassiadou, Pauline, Grapsa, Dimitra, Athanassiades, Peter, Gonidi, Maria, Athanassiadou, Anna-Maria, Tsipis, Angelos, Patsouris, Efstratios
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
COX-2
Cyclooxygenase 2 - analysis
Disease Progression
Female
Humans
Immunocytochemistry
Immunohistochemistry
Inhibitor of Apoptosis Proteins
Kaplan-Meier Estimate
Microtubule-Associated Proteins - analysis
Middle Aged
Neoplasm Proteins - analysis
Neoplasm Staging
Ovarian cancer
Ovarian Neoplasms - chemistry
Ovarian Neoplasms - enzymology
Ovarian Neoplasms - mortality
Ovarian Neoplasms - pathology
Ovarian Neoplasms - therapy
Prognosis
Proportional Hazards Models
Prospective Studies
Risk Assessment
Survivin
Time Factors
Treatment Outcome
Up-Regulation
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Summary:We investigated the prognostic significance of cyclooxygenase-2 (COX-2) and survivin in ovarian carcinoma. Imprint smears were obtained from 100 ovarian carcinoma specimens and were studied immunocytochemically for the expression of COX-2 and survivin. The results were correlated with several clinicopathological parameters, including 5-year survival. Increased COX-2 staining pattern correlated with a non-mucinous histological type ( p=0.008), increased stage ( p
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2007.11.004