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The prognostic significance of COX-2 and survivin expression in ovarian cancer
We investigated the prognostic significance of cyclooxygenase-2 (COX-2) and survivin in ovarian carcinoma. Imprint smears were obtained from 100 ovarian carcinoma specimens and were studied immunocytochemically for the expression of COX-2 and survivin. The results were correlated with several clinic...
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| Published in: | Pathology, research and practice research and practice, 2008-01, Vol.204 (4), p.241-249 |
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| container_title | Pathology, research and practice |
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| creator | Athanassiadou, Pauline Grapsa, Dimitra Athanassiades, Peter Gonidi, Maria Athanassiadou, Anna-Maria Tsipis, Angelos Patsouris, Efstratios |
| description | We investigated the prognostic significance of cyclooxygenase-2 (COX-2) and survivin in ovarian carcinoma.
Imprint smears were obtained from 100 ovarian carcinoma specimens and were studied immunocytochemically for the expression of COX-2 and survivin. The results were correlated with several clinicopathological parameters, including 5-year survival.
Increased COX-2 staining pattern correlated with a non-mucinous histological type (
p=0.008), increased stage (
p |
| doi_str_mv | 10.1016/j.prp.2007.11.004 |
| format | article |
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Imprint smears were obtained from 100 ovarian carcinoma specimens and were studied immunocytochemically for the expression of COX-2 and survivin. The results were correlated with several clinicopathological parameters, including 5-year survival.
Increased COX-2 staining pattern correlated with a non-mucinous histological type (
p=0.008), increased stage (
p<0.0001), high histological grade (
p<0.0001), and reduced survival rates (
p<0.00001). Survivin expression was strongly associated with increased stage (
p<0.0001), increased histological grade (
p<0.0001), and reduced survival (
p<0.00001). Elevated survivin expression also correlated significantly with pre-menopausal status (
p=0.033). In addition, COX-2 and survivin staining patterns correlated strongly with one another (
p<0.0001). However, on multivariate analysis, an independent prognostic value was found only for tumor stage and grade.
The findings of our study indicate that the increased expression of COX-2 and survivin in ovarian cancer is associated with one another and with several adverse clinicopathologic parameters, including reduced survival, thus suggesting a role of these molecules in disease progression. Further investigations of the exact prognostic and therapeutic implications of COX-2 and survivin expression are strongly warranted.]]></description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2007.11.004</identifier><identifier>PMID: 18171606</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; COX-2 ; Cyclooxygenase 2 - analysis ; Disease Progression ; Female ; Humans ; Immunocytochemistry ; Immunohistochemistry ; Inhibitor of Apoptosis Proteins ; Kaplan-Meier Estimate ; Microtubule-Associated Proteins - analysis ; Middle Aged ; Neoplasm Proteins - analysis ; Neoplasm Staging ; Ovarian cancer ; Ovarian Neoplasms - chemistry ; Ovarian Neoplasms - enzymology ; Ovarian Neoplasms - mortality ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - therapy ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Risk Assessment ; Survivin ; Time Factors ; Treatment Outcome ; Up-Regulation</subject><ispartof>Pathology, research and practice, 2008-01, Vol.204 (4), p.241-249</ispartof><rights>2007 Elsevier GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-563a8a770fd5d80d2f8752931e73f208e11eb8159e1c12b459a638d2c62d6a353</citedby><cites>FETCH-LOGICAL-c417t-563a8a770fd5d80d2f8752931e73f208e11eb8159e1c12b459a638d2c62d6a353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18171606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Athanassiadou, Pauline</creatorcontrib><creatorcontrib>Grapsa, Dimitra</creatorcontrib><creatorcontrib>Athanassiades, Peter</creatorcontrib><creatorcontrib>Gonidi, Maria</creatorcontrib><creatorcontrib>Athanassiadou, Anna-Maria</creatorcontrib><creatorcontrib>Tsipis, Angelos</creatorcontrib><creatorcontrib>Patsouris, Efstratios</creatorcontrib><title>The prognostic significance of COX-2 and survivin expression in ovarian cancer</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description><![CDATA[We investigated the prognostic significance of cyclooxygenase-2 (COX-2) and survivin in ovarian carcinoma.
Imprint smears were obtained from 100 ovarian carcinoma specimens and were studied immunocytochemically for the expression of COX-2 and survivin. The results were correlated with several clinicopathological parameters, including 5-year survival.
Increased COX-2 staining pattern correlated with a non-mucinous histological type (
p=0.008), increased stage (
p<0.0001), high histological grade (
p<0.0001), and reduced survival rates (
p<0.00001). Survivin expression was strongly associated with increased stage (
p<0.0001), increased histological grade (
p<0.0001), and reduced survival (
p<0.00001). Elevated survivin expression also correlated significantly with pre-menopausal status (
p=0.033). In addition, COX-2 and survivin staining patterns correlated strongly with one another (
p<0.0001). However, on multivariate analysis, an independent prognostic value was found only for tumor stage and grade.
The findings of our study indicate that the increased expression of COX-2 and survivin in ovarian cancer is associated with one another and with several adverse clinicopathologic parameters, including reduced survival, thus suggesting a role of these molecules in disease progression. Further investigations of the exact prognostic and therapeutic implications of COX-2 and survivin expression are strongly warranted.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>COX-2</subject><subject>Cyclooxygenase 2 - analysis</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Immunocytochemistry</subject><subject>Immunohistochemistry</subject><subject>Inhibitor of Apoptosis Proteins</subject><subject>Kaplan-Meier Estimate</subject><subject>Microtubule-Associated Proteins - analysis</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - analysis</subject><subject>Neoplasm Staging</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - chemistry</subject><subject>Ovarian Neoplasms - enzymology</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - therapy</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Survivin</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Up-Regulation</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kM1LAzEQxYMotn78AV4kJ2-7zmx2symepPgFYi8K3kKazNaUdndN2qL_vaktePM0zPB7j3mPsQuEHAHl9TzvQ58XAHWOmAOUB2yIElUGUuAhG4IoywyEUAN2EuMcEgglHrMBKqxRghyyl9cP4n3oZm0XV97y6Getb7w1rSXeNXw8ec8KblrH4zps_Ma3nL76QDH6ruVp6zYmeNPyX0U4Y0eNWUQ6389T9nZ_9zp-zJ4nD0_j2-fMllivskoKo0xdQ-Mqp8AVjaqrYiSQatEUoAiRpgqrEaHFYlpWIyOFcoWVhZNGVOKUXe180-ufa4orvfTR0mJhWurWUW9zApaQQNyBNnQxBmp0H_zShG-NoLcl6nm69HpbokbUqcSkudybr6dLcn-KfWsJuNkBlCJuPAUdraeU3_lAdqVd5_-x_wFyYIEu</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Athanassiadou, Pauline</creator><creator>Grapsa, Dimitra</creator><creator>Athanassiades, Peter</creator><creator>Gonidi, Maria</creator><creator>Athanassiadou, Anna-Maria</creator><creator>Tsipis, Angelos</creator><creator>Patsouris, Efstratios</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>The prognostic significance of COX-2 and survivin expression in ovarian cancer</title><author>Athanassiadou, Pauline ; Grapsa, Dimitra ; Athanassiades, Peter ; Gonidi, Maria ; Athanassiadou, Anna-Maria ; Tsipis, Angelos ; Patsouris, Efstratios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-563a8a770fd5d80d2f8752931e73f208e11eb8159e1c12b459a638d2c62d6a353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>COX-2</topic><topic>Cyclooxygenase 2 - analysis</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Immunocytochemistry</topic><topic>Immunohistochemistry</topic><topic>Inhibitor of Apoptosis Proteins</topic><topic>Kaplan-Meier Estimate</topic><topic>Microtubule-Associated Proteins - analysis</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - analysis</topic><topic>Neoplasm Staging</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - chemistry</topic><topic>Ovarian Neoplasms - enzymology</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - therapy</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Survivin</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Athanassiadou, Pauline</creatorcontrib><creatorcontrib>Grapsa, Dimitra</creatorcontrib><creatorcontrib>Athanassiades, Peter</creatorcontrib><creatorcontrib>Gonidi, Maria</creatorcontrib><creatorcontrib>Athanassiadou, Anna-Maria</creatorcontrib><creatorcontrib>Tsipis, Angelos</creatorcontrib><creatorcontrib>Patsouris, Efstratios</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Athanassiadou, Pauline</au><au>Grapsa, Dimitra</au><au>Athanassiades, Peter</au><au>Gonidi, Maria</au><au>Athanassiadou, Anna-Maria</au><au>Tsipis, Angelos</au><au>Patsouris, Efstratios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic significance of COX-2 and survivin expression in ovarian cancer</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>204</volume><issue>4</issue><spage>241</spage><epage>249</epage><pages>241-249</pages><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract><![CDATA[We investigated the prognostic significance of cyclooxygenase-2 (COX-2) and survivin in ovarian carcinoma.
Imprint smears were obtained from 100 ovarian carcinoma specimens and were studied immunocytochemically for the expression of COX-2 and survivin. The results were correlated with several clinicopathological parameters, including 5-year survival.
Increased COX-2 staining pattern correlated with a non-mucinous histological type (
p=0.008), increased stage (
p<0.0001), high histological grade (
p<0.0001), and reduced survival rates (
p<0.00001). Survivin expression was strongly associated with increased stage (
p<0.0001), increased histological grade (
p<0.0001), and reduced survival (
p<0.00001). Elevated survivin expression also correlated significantly with pre-menopausal status (
p=0.033). In addition, COX-2 and survivin staining patterns correlated strongly with one another (
p<0.0001). However, on multivariate analysis, an independent prognostic value was found only for tumor stage and grade.
The findings of our study indicate that the increased expression of COX-2 and survivin in ovarian cancer is associated with one another and with several adverse clinicopathologic parameters, including reduced survival, thus suggesting a role of these molecules in disease progression. Further investigations of the exact prognostic and therapeutic implications of COX-2 and survivin expression are strongly warranted.]]></abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>18171606</pmid><doi>10.1016/j.prp.2007.11.004</doi><tpages>9</tpages></addata></record> |
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| source | Elsevier |
| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis COX-2 Cyclooxygenase 2 - analysis Disease Progression Female Humans Immunocytochemistry Immunohistochemistry Inhibitor of Apoptosis Proteins Kaplan-Meier Estimate Microtubule-Associated Proteins - analysis Middle Aged Neoplasm Proteins - analysis Neoplasm Staging Ovarian cancer Ovarian Neoplasms - chemistry Ovarian Neoplasms - enzymology Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Prognosis Proportional Hazards Models Prospective Studies Risk Assessment Survivin Time Factors Treatment Outcome Up-Regulation |
| title | The prognostic significance of COX-2 and survivin expression in ovarian cancer |
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