Interpreting tests for iron deficiency among adults in a high HIV prevalence African setting: routine tests may lead to misdiagnosis

We evaluated peripheral blood tests to diagnose iron deficiency on medical wards in Blantyre, Malawi, where infection and HIV are prevalent. We compared full blood count, ferritin and serum transferrin receptor (TfR) levels with an estimation of iron in bone marrow aspirates. Of consecutive adults a...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2007-06, Vol.101 (6), p.613-617
Main Authors: Lewis, David K., Whitty, Christopher J.M., Epino, Henry, Letsky, Elizabeth A., Mukiibi, Joshua M., van den Broek, Nynke R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - diagnosis
Anemias. Hemoglobinopathies
Biological and medical sciences
Bone marrow
Diagnosis
Diseases of red blood cells
Female
Ferritins - blood
Hematologic and hematopoietic diseases
HIV
HIV Infections - complications
Humans
Iron deficiency anaemia
Malawi
Male
Medical sciences
Metabolic diseases
Metals (hemochromatosis...)
Middle Aged
Other metabolic disorders
Pregnancy
Receptors, Transferrin - blood
Reproducibility of Results
ROC Curve
Sensitivity and Specificity
Sub-Saharan Africa
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Summary:We evaluated peripheral blood tests to diagnose iron deficiency on medical wards in Blantyre, Malawi, where infection and HIV are prevalent. We compared full blood count, ferritin and serum transferrin receptor (TfR) levels with an estimation of iron in bone marrow aspirates. Of consecutive adults admitted with severe anaemia (haemoglobin
ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2006.11.004