Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities

• Published in: Phytochemistry (Oxford) 2007-05, Vol.68 (9), p.1338-1343
• Main Authors: Wu, Che-Chen, Peng, Chien-Fang, Tsai, Ian-Lih, Abd El-Razek, Mohamed H., Huang, He-Shun, Chen, Ih-Sheng
• Format: Article
• Language: English
• Subjects: Antitubercular activity; Antitubercular Agents - chemistry; Antitubercular Agents - metabolism; Antitubercular Agents - pharmacology; Biological and medical sciences; Butanolide; Chemical constitution; Engelhardia roxburghiana; Engelhardic acid; Engelharolide; Engelharquinone; Engelharquinone epoxide; Fundamental and applied biological sciences. Psychology; General pharmacology; Juglandaceae; Juglandaceae - chemistry; Juglandaceae - metabolism; Medical sciences; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis - drug effects; Naphthoquinones; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant physiology and development; Plant Roots - chemistry; Plant Roots - metabolism; Root; Sesquiterpene
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2007.01.018

Engelharquinone ( 1) engelharquinone epoxide ( 2), engelharolide ( 3), and engelhardic acid ( 4), were isolate and identify for the first time from a plant source together with 20 previously known compounds, four of which were not reported as plant constituents previously. A biological evaluation showed that three of the previously isolated antitubercular constituents [(−)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone ( 1) exhibited moderate antitubercular activity against Mycobacterium tuberculosis 90-221387. Engelharquinone ( 1), engelharquinone epoxide ( 2), engelharolide ( 3), and engelhardic acid ( 4), were isolated as naturally occurring products from a plant source, Engelhardia roxburghiana together with 20 previously known compounds, four of which were hitherto not known as plant constituents. Their structures were identified by means of spectroscopic analysis. A biological evaluation showed that three of the previously isolated antitubercular constituents [(−)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone ( 1) exhibited moderate antitubercular activity against Mycobacterium tuberculosis 90-221387.