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Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities
Engelharquinone ( 1) engelharquinone epoxide ( 2), engelharolide ( 3), and engelhardic acid ( 4), were isolate and identify for the first time from a plant source together with 20 previously known compounds, four of which were not reported as plant constituents previously. A biological evaluation sh...
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| Published in: | Phytochemistry (Oxford) 2007-05, Vol.68 (9), p.1338-1343 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c399t-f3b28a8fca3c91eec2067eed112d9edd36010efa268b551de91ba654d3cc7ef53 |
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| container_end_page | 1343 |
| container_issue | 9 |
| container_start_page | 1338 |
| container_title | Phytochemistry (Oxford) |
| container_volume | 68 |
| creator | Wu, Che-Chen Peng, Chien-Fang Tsai, Ian-Lih Abd El-Razek, Mohamed H. Huang, He-Shun Chen, Ih-Sheng |
| description | Engelharquinone (
1) engelharquinone epoxide (
2), engelharolide (
3), and engelhardic acid (
4), were isolate and identify for the first time from a plant source together with 20 previously known compounds, four of which were not reported as plant constituents previously. A biological evaluation showed that three of the previously isolated antitubercular constituents [(−)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (
1) exhibited moderate antitubercular activity against
Mycobacterium tuberculosis 90-221387.
Engelharquinone (
1), engelharquinone epoxide (
2), engelharolide (
3), and engelhardic acid (
4), were isolated as naturally occurring products from a plant source,
Engelhardia roxburghiana together with 20 previously known compounds, four of which were hitherto not known as plant constituents. Their structures were identified by means of spectroscopic analysis. A biological evaluation showed that three of the previously isolated antitubercular constituents [(−)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (
1) exhibited moderate antitubercular activity against
Mycobacterium tuberculosis 90-221387. |
| doi_str_mv | 10.1016/j.phytochem.2007.01.018 |
| format | article |
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1) engelharquinone epoxide (
2), engelharolide (
3), and engelhardic acid (
4), were isolate and identify for the first time from a plant source together with 20 previously known compounds, four of which were not reported as plant constituents previously. A biological evaluation showed that three of the previously isolated antitubercular constituents [(−)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (
1) exhibited moderate antitubercular activity against
Mycobacterium tuberculosis 90-221387.
Engelharquinone (
1), engelharquinone epoxide (
2), engelharolide (
3), and engelhardic acid (
4), were isolated as naturally occurring products from a plant source,
Engelhardia roxburghiana together with 20 previously known compounds, four of which were hitherto not known as plant constituents. Their structures were identified by means of spectroscopic analysis. A biological evaluation showed that three of the previously isolated antitubercular constituents [(−)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (
1) exhibited moderate antitubercular activity against
Mycobacterium tuberculosis 90-221387.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/j.phytochem.2007.01.018</identifier><identifier>PMID: 17418287</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Antitubercular activity ; Antitubercular Agents - chemistry ; Antitubercular Agents - metabolism ; Antitubercular Agents - pharmacology ; Biological and medical sciences ; Butanolide ; Chemical constitution ; Engelhardia roxburghiana ; Engelhardic acid ; Engelharolide ; Engelharquinone ; Engelharquinone epoxide ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Juglandaceae ; Juglandaceae - chemistry ; Juglandaceae - metabolism ; Medical sciences ; Microbial Sensitivity Tests ; Molecular Structure ; Mycobacterium tuberculosis - drug effects ; Naphthoquinones ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant physiology and development ; Plant Roots - chemistry ; Plant Roots - metabolism ; Root ; Sesquiterpene</subject><ispartof>Phytochemistry (Oxford), 2007-05, Vol.68 (9), p.1338-1343</ispartof><rights>2007 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-f3b28a8fca3c91eec2067eed112d9edd36010efa268b551de91ba654d3cc7ef53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18738890$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17418287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Che-Chen</creatorcontrib><creatorcontrib>Peng, Chien-Fang</creatorcontrib><creatorcontrib>Tsai, Ian-Lih</creatorcontrib><creatorcontrib>Abd El-Razek, Mohamed H.</creatorcontrib><creatorcontrib>Huang, He-Shun</creatorcontrib><creatorcontrib>Chen, Ih-Sheng</creatorcontrib><title>Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>Engelharquinone (
1) engelharquinone epoxide (
2), engelharolide (
3), and engelhardic acid (
4), were isolate and identify for the first time from a plant source together with 20 previously known compounds, four of which were not reported as plant constituents previously. A biological evaluation showed that three of the previously isolated antitubercular constituents [(−)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (
1) exhibited moderate antitubercular activity against
Mycobacterium tuberculosis 90-221387.
Engelharquinone (
1), engelharquinone epoxide (
2), engelharolide (
3), and engelhardic acid (
4), were isolated as naturally occurring products from a plant source,
Engelhardia roxburghiana together with 20 previously known compounds, four of which were hitherto not known as plant constituents. Their structures were identified by means of spectroscopic analysis. A biological evaluation showed that three of the previously isolated antitubercular constituents [(−)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (
1) exhibited moderate antitubercular activity against
Mycobacterium tuberculosis 90-221387.</description><subject>Antitubercular activity</subject><subject>Antitubercular Agents - chemistry</subject><subject>Antitubercular Agents - metabolism</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Butanolide</subject><subject>Chemical constitution</subject><subject>Engelhardia roxburghiana</subject><subject>Engelhardic acid</subject><subject>Engelharolide</subject><subject>Engelharquinone</subject><subject>Engelharquinone epoxide</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Juglandaceae</subject><subject>Juglandaceae - chemistry</subject><subject>Juglandaceae - metabolism</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Structure</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Naphthoquinones</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant physiology and development</subject><subject>Plant Roots - chemistry</subject><subject>Plant Roots - metabolism</subject><subject>Root</subject><subject>Sesquiterpene</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkMFu3CAQhlHVqNmkfYXWl_bm7QC2wccoSpNKkXpoekYYhpiVbbaAo-Tty2pXybHSSDDo-2fQR8gXClsKtPu-2-7HlxzMiPOWAYgt0FLyHdlQKXjNBcB7sgHgtO4bxs7JRUo7AGjbrvtAzqloqGRSbIj9jSYsVseXasashzD5jKlyMcxVHrGKIeRUBVfdLI84jTpar8vj87DGx9HrRVd6sQfSx3LLPq8DRrNOurQm-yefPaaP5MzpKeGn03lJ_vy4ebi-q-9_3f68vrqvDe_7XDs-MKmlM5qbniIaBp1AtJQy26O1vAMK6DTr5NC21GJPB921jeXGCHQtvyTfjnP3MfxdMWU1-2RwmvSCYU1KQEObHlgBxRE0MaQU0al99HORoCiog2C1U6-C1UGwAlpKluTn04p1mNG-5U5GC_D1BOhk9OSiXoxPb1xBpOyhcFdHDouQJ49RJeNxMWh9RJOVDf6_n_kHZGShIg</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Wu, Che-Chen</creator><creator>Peng, Chien-Fang</creator><creator>Tsai, Ian-Lih</creator><creator>Abd El-Razek, Mohamed H.</creator><creator>Huang, He-Shun</creator><creator>Chen, Ih-Sheng</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities</title><author>Wu, Che-Chen ; Peng, Chien-Fang ; Tsai, Ian-Lih ; Abd El-Razek, Mohamed H. ; Huang, He-Shun ; Chen, Ih-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-f3b28a8fca3c91eec2067eed112d9edd36010efa268b551de91ba654d3cc7ef53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antitubercular activity</topic><topic>Antitubercular Agents - chemistry</topic><topic>Antitubercular Agents - metabolism</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Butanolide</topic><topic>Chemical constitution</topic><topic>Engelhardia roxburghiana</topic><topic>Engelhardic acid</topic><topic>Engelharolide</topic><topic>Engelharquinone</topic><topic>Engelharquinone epoxide</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Juglandaceae</topic><topic>Juglandaceae - chemistry</topic><topic>Juglandaceae - metabolism</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Structure</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Naphthoquinones</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant physiology and development</topic><topic>Plant Roots - chemistry</topic><topic>Plant Roots - metabolism</topic><topic>Root</topic><topic>Sesquiterpene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Che-Chen</creatorcontrib><creatorcontrib>Peng, Chien-Fang</creatorcontrib><creatorcontrib>Tsai, Ian-Lih</creatorcontrib><creatorcontrib>Abd El-Razek, Mohamed H.</creatorcontrib><creatorcontrib>Huang, He-Shun</creatorcontrib><creatorcontrib>Chen, Ih-Sheng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemistry (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Che-Chen</au><au>Peng, Chien-Fang</au><au>Tsai, Ian-Lih</au><au>Abd El-Razek, Mohamed H.</au><au>Huang, He-Shun</au><au>Chen, Ih-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities</atitle><jtitle>Phytochemistry (Oxford)</jtitle><addtitle>Phytochemistry</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>68</volume><issue>9</issue><spage>1338</spage><epage>1343</epage><pages>1338-1343</pages><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>Engelharquinone (
1) engelharquinone epoxide (
2), engelharolide (
3), and engelhardic acid (
4), were isolate and identify for the first time from a plant source together with 20 previously known compounds, four of which were not reported as plant constituents previously. A biological evaluation showed that three of the previously isolated antitubercular constituents [(−)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (
1) exhibited moderate antitubercular activity against
Mycobacterium tuberculosis 90-221387.
Engelharquinone (
1), engelharquinone epoxide (
2), engelharolide (
3), and engelhardic acid (
4), were isolated as naturally occurring products from a plant source,
Engelhardia roxburghiana together with 20 previously known compounds, four of which were hitherto not known as plant constituents. Their structures were identified by means of spectroscopic analysis. A biological evaluation showed that three of the previously isolated antitubercular constituents [(−)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (
1) exhibited moderate antitubercular activity against
Mycobacterium tuberculosis 90-221387.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>17418287</pmid><doi>10.1016/j.phytochem.2007.01.018</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9422 |
| ispartof | Phytochemistry (Oxford), 2007-05, Vol.68 (9), p.1338-1343 |
| issn | 0031-9422 1873-3700 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70414902 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Antitubercular activity Antitubercular Agents - chemistry Antitubercular Agents - metabolism Antitubercular Agents - pharmacology Biological and medical sciences Butanolide Chemical constitution Engelhardia roxburghiana Engelhardic acid Engelharolide Engelharquinone Engelharquinone epoxide Fundamental and applied biological sciences. Psychology General pharmacology Juglandaceae Juglandaceae - chemistry Juglandaceae - metabolism Medical sciences Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis - drug effects Naphthoquinones Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant physiology and development Plant Roots - chemistry Plant Roots - metabolism Root Sesquiterpene |
| title | Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities |
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