D-dimer identifies stages in the progression of diabetes mellitus from family history of diabetes to cardiovascular complications

The aim of the study was to ascertain whether there is variation in the fibrinolytic/coagulation component of diabetes associated with disease progression to macrovascular complications and whether D-dimer can discriminate such variation. A total of 343 participants were selected based on clinical s...

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Bibliographic Details
Published in:Pathology 2007-04, Vol.39 (2), p.252-257
Main Authors: Nwose, Ezekiel U., Richards, Ross S., Jelinek, Herbert F., Kerr, Philip G.
Format: Article
Language:English
Subjects:
Biomarkers - blood
cardiovascular
Coagulation
Coronary Artery Disease - blood
Coronary Artery Disease - complications
Diabetes Complications - blood
diabetes mellitus
Diabetes Mellitus - blood
Disease Progression
Female
Fibrin Fibrinogen Degradation Products - analysis
Humans
Male
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Summary:The aim of the study was to ascertain whether there is variation in the fibrinolytic/coagulation component of diabetes associated with disease progression to macrovascular complications and whether D-dimer can discriminate such variation. A total of 343 participants were selected based on clinical status and divided into 7 groups: control, family history of diabetes, pre-diabetes with/without CVD, diabetes with/without CVD and CVD only. Plasma D-dimer was tested. Statistical analysis was performed on log normalised data by ANOVA, Fisher’s LSD post hoc test. After the initial analysis, data were classified and re-analysed by quartiles, interquartile range and 95th percentile. An overall significant difference between groups (p
ISSN:0031-3025
1465-3931
DOI:10.1080/00313020701230658