Contrast-Enhanced FDG-PET CT vs. SPIO-Enhanced MRI vs. FDG-PET vs. CT in Patients with Liver Metastases from Colorectal Cancer: A Prospective Study with Intraoperative Confirmation

Background: The choice of imaging before liver surgery is debated regarding the use of magnetic resonance (MR) imaging, computed tomography (CT), and positron emission tomography (PET). No studies have compared contrast-enhanced PET CT with superparamagnetic iron oxide (SPIO)-enhanced MR imaging. Pu...

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Published in:Acta radiologica (1987) 2007-05, Vol.48 (4), p.369-378
Main Authors: Rappeport, E. D., Loft, A., Berthelsen, A. K., von der Recke, P., Noergaard Larsen, P., Mellon Mogensen, A., Wettergren, A., Rasmussen, A., Hillingsoe, J., Kirkegaard, P., Thomsen, C.
Format: Article
Language:English
Subjects:
Abdominal Neoplasms - secondary
Adult
Aged
Colonic Neoplasms - pathology
Contrast Media
Dextrans
Female
Ferrosoferric Oxide
Fluorodeoxyglucose F18
Humans
Image Enhancement - methods
Iron
Liver Neoplasms - diagnosis
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Lung Neoplasms - secondary
Lymphatic Metastasis - diagnosis
Magnetic Resonance Imaging - methods
Magnetite Nanoparticles
Male
Middle Aged
Oxides
Peritoneal Neoplasms - secondary
Positron-Emission Tomography - methods
Prospective Studies
Radiopharmaceuticals
Rectal Neoplasms - pathology
Sensitivity and Specificity
Tomography, X-Ray Computed - methods
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Summary:Background: The choice of imaging before liver surgery is debated regarding the use of magnetic resonance (MR) imaging, computed tomography (CT), and positron emission tomography (PET). No studies have compared contrast-enhanced PET CT with superparamagnetic iron oxide (SPIO)-enhanced MR imaging. Purpose: To compare PET CT with superparamagnetic iron oxide (SPIO)-enhanced MR imaging, PET, and CT in the detection of liver metastases (LM) and extrahepatic tumor from colorectal cancer (CRC). Material and Methods: Thirty-five patients with suspected LM underwent PET CT with a contrast-enhanced CT protocol and SPIO-enhanced MR imaging. Readers independently analyzed images from MR imaging, PET CT, and the CT part and PET part of the PET CT study. Imaging findings were compared with surgical and histological findings. Results: Lesion-by-lesion sensitivity and accuracy for liver lesions was 54% and 77% for PET alone, 66% and 83% for PET CT, 82% and 82% for SPIO-enhanced MR imaging, and 89% and 77% for CT alone, respectively. CT and SPIO-enhanced MR imaging were less specific but significantly more sensitive than PET (P
ISSN:0284-1851
1600-0455
DOI:10.1080/02841850701294560