Microbiaeratin, a New Natural Indole Alkaloid from a Microbispora aerata Strain, Isolated from Livingston Island, Antarctica

A new sulphur-containing natural alkaloid named microbiaeratin (1a) was isolated, together with the known microbiaeratinin (2, bacillamide) from the culture filtrate of Microbispora aerata strain IMBAS-11A. The organism was isolated from penguin excrements collected on the Antarctic Livingston Islan...

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Bibliographic Details
Published in:Preparative biochemistry & biotechnology 2007-04, Vol.37 (2), p.161-168
Main Authors: Ivanova, Veneta, Kolarova, Mariana, Aleksieva, Krasja, Gräfe, Udo, Dahse, Hans-Martin, Laatsch, Hartmut
Format: Article
Language:English
Subjects:
Actinomycetales - chemistry
Actinomycetales - genetics
Actinomycetales - physiology
Animals
Antarctic Regions
Bacillamide
Bacteria - drug effects
Bacteria - growth & development
Cell Line, Tumor - drug effects
Chromatography, High Pressure Liquid
Feces - chemistry
Feces - microbiology
Fibroblasts - cytology
Fibroblasts - drug effects
Humans
Indole Alkaloids - chemistry
Indole Alkaloids - isolation & purification
Indole Alkaloids - pharmacology
Mice
Microbiaeratin
Microbiaeratinin
Microbispora aerata
Molecular Structure
Spectrum Analysis
Spheniscidae
Sulfur - chemistry
Sulphur-containing indole alkaloids
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Summary:A new sulphur-containing natural alkaloid named microbiaeratin (1a) was isolated, together with the known microbiaeratinin (2, bacillamide) from the culture filtrate of Microbispora aerata strain IMBAS-11A. The organism was isolated from penguin excrements collected on the Antarctic Livingston Island. The structure was elucidated by one- and two-dimensional NMR experiments and mass spectrometric investigations.
ISSN:1082-6068
1532-2297
DOI:10.1080/10826060701199122