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Oral administration of phytocomponent p-hydroxycinnamic acid prevents bone loss in ovariectomized rats
The preventive effect of phytocomponent p-hydroxycinnamic acid (HCA) on ovariectomy (OVX)-induced bone loss was investigated. HCA (250 or 500 μg/100 g body weight) was orally administered once daily for 30 days to OVX rats. The analysis using a peripheral quantitative computed tomography (pQCT) show...
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| Published in: | Molecular and cellular biochemistry 2008-04, Vol.311 (1-2), p.31-36 |
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| container_end_page | 36 |
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| container_title | Molecular and cellular biochemistry |
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| creator | Yamaguchi, Masayoshi Lai, Ying Ling Uchiyama, Satoshi Nakagawa, Taeko |
| description | The preventive effect of phytocomponent p-hydroxycinnamic acid (HCA) on ovariectomy (OVX)-induced bone loss was investigated. HCA (250 or 500 μg/100 g body weight) was orally administered once daily for 30 days to OVX rats. The analysis using a peripheral quantitative computed tomography (pQCT) showed that OVX caused bone loss in the femoral-metaphyseal tissues. This change was significantly restored after the administration of HCA (250 or 500 μg/100 g body weight) to OVX rats. Mineral content, mineral density, and polar strength strain index in the femoral-metaphyseal tissues were significantly decreased in OVX rats. These decreases were significantly restored after the administration of HCA (500 μg/100 g) to OVX rats. Moreover, OVX caused a significant decrease in calcium content or alkaline phosphatase activity in the femoral-diaphyseal and -metaphyseal tissues. These decreases were significantly restored after the administration of HCA (250 or 500 μg/100 g) to OVX rats. Deoxyribonucleic acid (DNA) content in the diaphyseal or metaphyseal tissues was significantly increased in OVX rats. These increases were significantly restored after oral administration of HCA (500 μg/100 g). This study demonstrates that HCA has preventive effects on OVX-induced bone loss of rats in vivo. |
| doi_str_mv | 10.1007/s11010-007-9689-x |
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HCA (250 or 500 μg/100 g body weight) was orally administered once daily for 30 days to OVX rats. The analysis using a peripheral quantitative computed tomography (pQCT) showed that OVX caused bone loss in the femoral-metaphyseal tissues. This change was significantly restored after the administration of HCA (250 or 500 μg/100 g body weight) to OVX rats. Mineral content, mineral density, and polar strength strain index in the femoral-metaphyseal tissues were significantly decreased in OVX rats. These decreases were significantly restored after the administration of HCA (500 μg/100 g) to OVX rats. Moreover, OVX caused a significant decrease in calcium content or alkaline phosphatase activity in the femoral-diaphyseal and -metaphyseal tissues. These decreases were significantly restored after the administration of HCA (250 or 500 μg/100 g) to OVX rats. Deoxyribonucleic acid (DNA) content in the diaphyseal or metaphyseal tissues was significantly increased in OVX rats. These increases were significantly restored after oral administration of HCA (500 μg/100 g). This study demonstrates that HCA has preventive effects on OVX-induced bone loss of rats in vivo.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-007-9689-x</identifier><identifier>PMID: 18165927</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Administration, Oral ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Body weight ; Bone and Bones - anatomy & histology ; Bone and Bones - drug effects ; Bone and Bones - metabolism ; Bone and Bones - pathology ; Bone Density - drug effects ; Bone Density Conservation Agents - administration & dosage ; Bone Density Conservation Agents - pharmacology ; Cardiology ; Computed tomography ; Coumaric Acids - administration & dosage ; Coumaric Acids - pharmacology ; Endocrinology ; Female ; Humans ; Life Sciences ; Medical Biochemistry ; Molecular biology ; Oncology ; Osteoporosis ; Osteoporosis, Postmenopausal - prevention & control ; Ovariectomy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Propionates ; Rats ; Rats, Wistar ; Rodents</subject><ispartof>Molecular and cellular biochemistry, 2008-04, Vol.311 (1-2), p.31-36</ispartof><rights>Springer Science+Business Media, LLC. 2007</rights><rights>Springer Science+Business Media, LLC. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-debee6e0956906101380b7550e334bb916fa2c6ceaba9364c80b3f7b3738fcf33</citedby><cites>FETCH-LOGICAL-c521t-debee6e0956906101380b7550e334bb916fa2c6ceaba9364c80b3f7b3738fcf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18165927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamaguchi, Masayoshi</creatorcontrib><creatorcontrib>Lai, Ying Ling</creatorcontrib><creatorcontrib>Uchiyama, Satoshi</creatorcontrib><creatorcontrib>Nakagawa, Taeko</creatorcontrib><title>Oral administration of phytocomponent p-hydroxycinnamic acid prevents bone loss in ovariectomized rats</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>The preventive effect of phytocomponent p-hydroxycinnamic acid (HCA) on ovariectomy (OVX)-induced bone loss was investigated. HCA (250 or 500 μg/100 g body weight) was orally administered once daily for 30 days to OVX rats. The analysis using a peripheral quantitative computed tomography (pQCT) showed that OVX caused bone loss in the femoral-metaphyseal tissues. This change was significantly restored after the administration of HCA (250 or 500 μg/100 g body weight) to OVX rats. Mineral content, mineral density, and polar strength strain index in the femoral-metaphyseal tissues were significantly decreased in OVX rats. These decreases were significantly restored after the administration of HCA (500 μg/100 g) to OVX rats. Moreover, OVX caused a significant decrease in calcium content or alkaline phosphatase activity in the femoral-diaphyseal and -metaphyseal tissues. These decreases were significantly restored after the administration of HCA (250 or 500 μg/100 g) to OVX rats. Deoxyribonucleic acid (DNA) content in the diaphyseal or metaphyseal tissues was significantly increased in OVX rats. These increases were significantly restored after oral administration of HCA (500 μg/100 g). This study demonstrates that HCA has preventive effects on OVX-induced bone loss of rats in vivo.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Body weight</subject><subject>Bone and Bones - anatomy & histology</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - pathology</subject><subject>Bone Density - drug effects</subject><subject>Bone Density Conservation Agents - administration & dosage</subject><subject>Bone Density Conservation Agents - pharmacology</subject><subject>Cardiology</subject><subject>Computed tomography</subject><subject>Coumaric Acids - administration & dosage</subject><subject>Coumaric Acids - pharmacology</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Medical Biochemistry</subject><subject>Molecular biology</subject><subject>Oncology</subject><subject>Osteoporosis</subject><subject>Osteoporosis, Postmenopausal - 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Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamaguchi, Masayoshi</au><au>Lai, Ying Ling</au><au>Uchiyama, Satoshi</au><au>Nakagawa, Taeko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral administration of phytocomponent p-hydroxycinnamic acid prevents bone loss in ovariectomized rats</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>311</volume><issue>1-2</issue><spage>31</spage><epage>36</epage><pages>31-36</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>The preventive effect of phytocomponent p-hydroxycinnamic acid (HCA) on ovariectomy (OVX)-induced bone loss was investigated. HCA (250 or 500 μg/100 g body weight) was orally administered once daily for 30 days to OVX rats. The analysis using a peripheral quantitative computed tomography (pQCT) showed that OVX caused bone loss in the femoral-metaphyseal tissues. This change was significantly restored after the administration of HCA (250 or 500 μg/100 g body weight) to OVX rats. Mineral content, mineral density, and polar strength strain index in the femoral-metaphyseal tissues were significantly decreased in OVX rats. These decreases were significantly restored after the administration of HCA (500 μg/100 g) to OVX rats. Moreover, OVX caused a significant decrease in calcium content or alkaline phosphatase activity in the femoral-diaphyseal and -metaphyseal tissues. These decreases were significantly restored after the administration of HCA (250 or 500 μg/100 g) to OVX rats. Deoxyribonucleic acid (DNA) content in the diaphyseal or metaphyseal tissues was significantly increased in OVX rats. These increases were significantly restored after oral administration of HCA (500 μg/100 g). This study demonstrates that HCA has preventive effects on OVX-induced bone loss of rats in vivo.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>18165927</pmid><doi>10.1007/s11010-007-9689-x</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Oral Animals Biochemistry Biomedical and Life Sciences Body weight Bone and Bones - anatomy & histology Bone and Bones - drug effects Bone and Bones - metabolism Bone and Bones - pathology Bone Density - drug effects Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - pharmacology Cardiology Computed tomography Coumaric Acids - administration & dosage Coumaric Acids - pharmacology Endocrinology Female Humans Life Sciences Medical Biochemistry Molecular biology Oncology Osteoporosis Osteoporosis, Postmenopausal - prevention & control Ovariectomy Plant Extracts - administration & dosage Plant Extracts - pharmacology Propionates Rats Rats, Wistar Rodents |
| title | Oral administration of phytocomponent p-hydroxycinnamic acid prevents bone loss in ovariectomized rats |
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