Complementary use of molecular and element-specific mass spectrometry for identification of selenium compounds related to human selenium metabolism

The aim of this paper is to give an overview of analytical data on the identification of selenium compounds in biological samples with relevance for selenium metabolism. Only studies applying the combination of element-specific inductively coupled plasma mass spectrometry as well as molecular electr...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2008-04, Vol.390 (7), p.1691-1706
Main Authors: Gammelgaard, Bente, Gabel-Jensen, Charlotte, Stürup, Stefan, Hansen, Helle Rüsz
Format: Article
Language:English
Subjects:
Analytical Chemistry
Animals
Bioanalytical methods
Biochemistry
Biological samples
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chromatography, Liquid - methods
Food Science
high performance liquid chromatography
Humans
Laboratory Medicine
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Mass spectrometry/inductively coupled mass spectrometry
Molecular Structure
Monitoring/Environmental Analysis
Neoplasms - prevention & control
Organoselenium Compounds - administration & dosage
Organoselenium Compounds - analysis
Organoselenium Compounds - metabolism
Plants - chemistry
Reproducibility of Results
Review
Saccharomyces cerevisiae - chemistry
Sensitivity and Specificity
speciation
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Summary:The aim of this paper is to give an overview of analytical data on the identification of selenium compounds in biological samples with relevance for selenium metabolism. Only studies applying the combination of element-specific inductively coupled plasma mass spectrometry as well as molecular electrospray mass spectrometry detection have been included. Hence, selenium compounds are only considered identified if molecular mass spectra obtained by analysis of the authentic biological sample have been provided. Selenium compounds identified in selenium-accumulating plants and yeast are included, as extracts from such plants and yeast have been widely used for examination of the cancer-preventive effect of selenium in cell lines, animal models and human intervention trials. Hence, these selenium compounds are available for absorption and further metabolism. Identification of selenium metabolites in simulated gastric and intestinal juice, intestinal epithelial tissue, liver and urine is described. Hence, selenium metabolites identified in relation to absorption, metabolism and excretion are included.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-007-1788-8