HN protein of Newcastle disease virus causes apoptosis in chicken embryo fibroblast cells

Newcastle disease virus (NDV), an avian paramyxovirus, induces apoptosis in chicken embryo fibroblast (CEF) cells. In the present investigation, the ability of haemagglutinin-neuraminidase (HN) protein of NDV to cause apoptosis in CEF cells was examined. The results revealed that cells expressing th...

Full description

Saved in:
Bibliographic Details
Published in:Archives of virology 2008-04, Vol.153 (4), p.749-754
Main Authors: Ravindra, P. V, Tiwari, Ashok K, Sharma, Bhaskar, Rajawat, Yogendra Singh, Ratta, Barkha, Palia, Sudesh, Sundaresan, N. R, Chaturvedi, Uttara, Aruna Kumar, G. B, Chindera, Kantaraja, Saxena, Meeta, Subudhi, P. K, Rai, Anant, Chauhan, R. S
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biomedical and Life Sciences
Biomedicine
Brief Report
Caspases - metabolism
Cells, Cultured
Chick Embryo - cytology
Fibroblasts - metabolism
Fibroblasts - pathology
Fibroblasts - virology
HN Protein - metabolism
Infectious Diseases
Medical Microbiology
Newcastle disease virus
Newcastle disease virus - metabolism
Newcastle disease virus - pathogenicity
Oxidative Stress
Paramyxovirus
Phosphatidylserines - metabolism
Proteins
Research centers
Up-Regulation
Virology
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Newcastle disease virus (NDV), an avian paramyxovirus, induces apoptosis in chicken embryo fibroblast (CEF) cells. In the present investigation, the ability of haemagglutinin-neuraminidase (HN) protein of NDV to cause apoptosis in CEF cells was examined. The results revealed that cells expressing the HN protein demonstrated decreased DNA content, phosphatidylserine exposure and increased cytoplasmic vacuolation. Up-regulation of caspase-1, -9, -8, -3, loss of mitochondrial transmembrane potential and an increase in oxidative stress were also observed in cells expressing the HN protein. Based on the above results it can be concluded that HN protein of NDV causes apoptosis in CEF cells.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-008-0057-2