TNFalpha-308G/A polymorphism as a risk factor for HPV associated cervical cancer in Indian population

Investigation of the potential association of single nucleotide polymorphisms (SNPs) at -308 G/A and -238 G/A of Tumor necrosis factor alpha (TNFalpha) with susceptibility to HPV-16 associated cervical cancer in Indian women. The study included 165 histologically confirmed cases with 45 precancer an...

Full description

Saved in:
Bibliographic Details
Published in:Cellular oncology : the official journal of the International Society for Cellular Oncology 2007, Vol.29 (3), p.249-256
Main Authors: Kohaar, Indu, Thakur, Nisha, Salhan, Sudha, Batra, Swaraj, Singh, Veena, Sharma, Anita, Sodhani, Pushpa, Das, B C, Sarkar, Debi P, Bharadwaj, Mausumi
Format: Article
Language:English
Subjects:
Adenine
Base Sequence
Case-Control Studies
DNA Mutational Analysis
European Continental Ancestry Group - genetics
Female
Genetic Predisposition to Disease - genetics
Genotype
Guanine
Human papillomavirus 16 - physiology
Humans
India - epidemiology
Middle Aged
Molecular Sequence Data
Polymorphism, Single Nucleotide - genetics
Precancerous Conditions - genetics
Prevalence
Promoter Regions, Genetic - genetics
Tumor Necrosis Factor-alpha - genetics
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - virology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Investigation of the potential association of single nucleotide polymorphisms (SNPs) at -308 G/A and -238 G/A of Tumor necrosis factor alpha (TNFalpha) with susceptibility to HPV-16 associated cervical cancer in Indian women. The study included 165 histologically confirmed cases with 45 precancer and 120 cancer patients and an equal number (165) of healthy controls with normal cervical cytology. PCR-RFLP was employed to analyze TNFalpha promoter polymorphisms, which were confirmed by direct sequencing. Both patients and controls were screened for Human Papillomavirus (HPV) infection. The frequency of -308 A allele in TNFalpha was significantly higher in cases compared with control subjects (21% in cases vs. 9% in controls; p
ISSN:1570-5870