Polymerase-Directed Synthesis of 2‘-Deoxy-2‘-fluoro-β-D-arabinonucleic Acids

A series of DNA polymerases were found to catalyze DNA-directed synthesis of 2‘-deoxy-2‘-fluoro-arabinonucleic acids (FANA) as well as FANA-directed DNA synthesis in vitro.

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Bibliographic Details
Published in:Journal of the American Chemical Society 2007-05, Vol.129 (17), p.5310-5311
Main Authors: Peng, Chang G, Damha, Masad J
Format: Article
Language:English
Subjects:
Aptamers, Nucleotide - chemical synthesis
Arabinonucleotides - chemical synthesis
Arabinose - analogs & derivatives
Arabinose - chemistry
Binding Sites
Directed Molecular Evolution
DNA Primers
DNA-Directed DNA Polymerase - chemistry
Ligands
Nucleic Acid Conformation
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Description
Summary:A series of DNA polymerases were found to catalyze DNA-directed synthesis of 2‘-deoxy-2‘-fluoro-arabinonucleic acids (FANA) as well as FANA-directed DNA synthesis in vitro.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja069100g