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Association between serotonin transporter gene polymorphisms and depressed mood caused by job stress in Japanese workers
To estimate the genetic factors influencing depressed mood caused by job stress, a total of 243 employees at a manufacturing company and a local hospital in Japan (mean age 40.8±10.3 years) were recruited with informed consent. The Brief Job Stress Questionnaire was used to assess the present status...
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| Published in: | International journal of molecular medicine 2008-04, Vol.21 (4), p.499-505 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 505 |
| container_issue | 4 |
| container_start_page | 499 |
| container_title | International journal of molecular medicine |
| container_volume | 21 |
| creator | Katsuyama, Hironobu Tomita, Masafumi Hidaka, Kazuo Fushimi, Shigeko Okuyama, Toshiko Watanabe, Yoko Tamechika, Yoshie Otsuki, Takemi Saijoh, Kiyofumi Sunami, Shigeo |
| description | To estimate the genetic factors influencing depressed mood caused by job
stress, a total of 243 employees at a manufacturing company and a local hospital
in Japan (mean age 40.8±10.3 years) were recruited with informed consent. The
Brief Job Stress Questionnaire was used to assess the present status of stress.
Alcohol consumption and smoking were assessed as lifestyle factors. DNA samples
were prepared to detect gene polymorphisms of serotonin transporter (5HTT), aldehyde
dehydrogenase 2, D2 dopamine receptor, and cytochrome p450 2A6. The relationship
between job stress, lifestyle factors and these polymorphisms was assessed for
each gender. The level of depressed mood for female subjects was significantly
higher among the carriers of two short (s/s) alleles of the 5HTT regulatory region
compared with the carriers of one (s/l) or two (l/l) long alleles (Mann-Whitney
U test, p |
| doi_str_mv | 10.3892/ijmm.21.4.499 |
| format | article |
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stress, a total of 243 employees at a manufacturing company and a local hospital
in Japan (mean age 40.8±10.3 years) were recruited with informed consent. The
Brief Job Stress Questionnaire was used to assess the present status of stress.
Alcohol consumption and smoking were assessed as lifestyle factors. DNA samples
were prepared to detect gene polymorphisms of serotonin transporter (5HTT), aldehyde
dehydrogenase 2, D2 dopamine receptor, and cytochrome p450 2A6. The relationship
between job stress, lifestyle factors and these polymorphisms was assessed for
each gender. The level of depressed mood for female subjects was significantly
higher among the carriers of two short (s/s) alleles of the 5HTT regulatory region
compared with the carriers of one (s/l) or two (l/l) long alleles (Mann-Whitney
U test, p<0.05). The odds ratio of depressed mood also confirmed this relationship
for the female subjects, whereas there was no relationship for the male subjects.
When social support was taken into consideration, the depressed mood score for
those who had high support was significantly lower than for those who had low
support, irrespective of 5HTT polymorphisms and gender. Job stress may elicit
biological responses that contribute to depressed mood in relation to 5HTT polymorphisms,
and social support may reduce depressed mood irrespective of 5HTT polymorphisms.</description><identifier>ISSN: 1107-3756</identifier><identifier>EISSN: 1791-244X</identifier><identifier>DOI: 10.3892/ijmm.21.4.499</identifier><identifier>PMID: 18360696</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Adult ; Base Sequence ; Depression - etiology ; Depression - genetics ; Depression - psychology ; DNA Primers - genetics ; Employment - psychology ; Female ; Humans ; Japan ; Job Satisfaction ; Life Style ; Male ; Middle Aged ; Multivariate Analysis ; Polymorphism, Genetic ; Serotonin Plasma Membrane Transport Proteins - genetics ; Surveys and Questionnaires</subject><ispartof>International journal of molecular medicine, 2008-04, Vol.21 (4), p.499-505</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-14b0cc3855ee378d80cb46f3b7a0fee5e941658778093a7d3edcbdeca3e5b3e93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18360696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katsuyama, Hironobu</creatorcontrib><creatorcontrib>Tomita, Masafumi</creatorcontrib><creatorcontrib>Hidaka, Kazuo</creatorcontrib><creatorcontrib>Fushimi, Shigeko</creatorcontrib><creatorcontrib>Okuyama, Toshiko</creatorcontrib><creatorcontrib>Watanabe, Yoko</creatorcontrib><creatorcontrib>Tamechika, Yoshie</creatorcontrib><creatorcontrib>Otsuki, Takemi</creatorcontrib><creatorcontrib>Saijoh, Kiyofumi</creatorcontrib><creatorcontrib>Sunami, Shigeo</creatorcontrib><title>Association between serotonin transporter gene polymorphisms and depressed mood caused by job stress in Japanese workers</title><title>International journal of molecular medicine</title><addtitle>Int J Mol Med</addtitle><description>To estimate the genetic factors influencing depressed mood caused by job
stress, a total of 243 employees at a manufacturing company and a local hospital
in Japan (mean age 40.8±10.3 years) were recruited with informed consent. The
Brief Job Stress Questionnaire was used to assess the present status of stress.
Alcohol consumption and smoking were assessed as lifestyle factors. DNA samples
were prepared to detect gene polymorphisms of serotonin transporter (5HTT), aldehyde
dehydrogenase 2, D2 dopamine receptor, and cytochrome p450 2A6. The relationship
between job stress, lifestyle factors and these polymorphisms was assessed for
each gender. The level of depressed mood for female subjects was significantly
higher among the carriers of two short (s/s) alleles of the 5HTT regulatory region
compared with the carriers of one (s/l) or two (l/l) long alleles (Mann-Whitney
U test, p<0.05). The odds ratio of depressed mood also confirmed this relationship
for the female subjects, whereas there was no relationship for the male subjects.
When social support was taken into consideration, the depressed mood score for
those who had high support was significantly lower than for those who had low
support, irrespective of 5HTT polymorphisms and gender. Job stress may elicit
biological responses that contribute to depressed mood in relation to 5HTT polymorphisms,
and social support may reduce depressed mood irrespective of 5HTT polymorphisms.</description><subject>Adult</subject><subject>Base Sequence</subject><subject>Depression - etiology</subject><subject>Depression - genetics</subject><subject>Depression - psychology</subject><subject>DNA Primers - genetics</subject><subject>Employment - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Job Satisfaction</subject><subject>Life Style</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Polymorphism, Genetic</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Surveys and Questionnaires</subject><issn>1107-3756</issn><issn>1791-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpFkctrGzEQh0VpaV499lp06iWsK61eq2MIeRLIJYXehB7jdl3vaqNZk_i_j4wdcpqB-fgx8w0h3zlbiM62v_rVMCxavpALae0ncsyN5U0r5Z_PtefMNMIofUROEFeMtUra7is54p3QTFt9TF4vEHPs_dznkQaYXwBGilDynMd-pHPxI065zFDoXxiBTnm9HXKZ_vU4IPVjogmmAoiQ6JBzotFvdn3Y0lUOFOfdjNakez_5ERDoSy7_oeAZ-bL0a4Rvh3pKfl9fPV3eNg-PN3eXFw9NFFrPDZeBxSg6pQCE6VLHYpB6KYLxbAmgwEquVWdMx6zwJglIMSSIXoAKAqw4JT_3uVPJzxvA2Q09Rliv6zZ5g84w2WqpeAWbPRhLRiywdFPpB1-2jjO3U-12ql3LnXRVdeV_HII3YYD0QR_cVuB8D2C9PPUp4wfz_piWy5qlmBJvQ8SL-g</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Katsuyama, Hironobu</creator><creator>Tomita, Masafumi</creator><creator>Hidaka, Kazuo</creator><creator>Fushimi, Shigeko</creator><creator>Okuyama, Toshiko</creator><creator>Watanabe, Yoko</creator><creator>Tamechika, Yoshie</creator><creator>Otsuki, Takemi</creator><creator>Saijoh, Kiyofumi</creator><creator>Sunami, Shigeo</creator><general>D.A. 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stress, a total of 243 employees at a manufacturing company and a local hospital
in Japan (mean age 40.8±10.3 years) were recruited with informed consent. The
Brief Job Stress Questionnaire was used to assess the present status of stress.
Alcohol consumption and smoking were assessed as lifestyle factors. DNA samples
were prepared to detect gene polymorphisms of serotonin transporter (5HTT), aldehyde
dehydrogenase 2, D2 dopamine receptor, and cytochrome p450 2A6. The relationship
between job stress, lifestyle factors and these polymorphisms was assessed for
each gender. The level of depressed mood for female subjects was significantly
higher among the carriers of two short (s/s) alleles of the 5HTT regulatory region
compared with the carriers of one (s/l) or two (l/l) long alleles (Mann-Whitney
U test, p<0.05). The odds ratio of depressed mood also confirmed this relationship
for the female subjects, whereas there was no relationship for the male subjects.
When social support was taken into consideration, the depressed mood score for
those who had high support was significantly lower than for those who had low
support, irrespective of 5HTT polymorphisms and gender. Job stress may elicit
biological responses that contribute to depressed mood in relation to 5HTT polymorphisms,
and social support may reduce depressed mood irrespective of 5HTT polymorphisms.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>18360696</pmid><doi>10.3892/ijmm.21.4.499</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1107-3756 |
| ispartof | International journal of molecular medicine, 2008-04, Vol.21 (4), p.499-505 |
| issn | 1107-3756 1791-244X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70426451 |
| source | Alma/SFX Local Collection |
| subjects | Adult Base Sequence Depression - etiology Depression - genetics Depression - psychology DNA Primers - genetics Employment - psychology Female Humans Japan Job Satisfaction Life Style Male Middle Aged Multivariate Analysis Polymorphism, Genetic Serotonin Plasma Membrane Transport Proteins - genetics Surveys and Questionnaires |
| title | Association between serotonin transporter gene polymorphisms and depressed mood caused by job stress in Japanese workers |
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