X-Inactivation: It Takes Two to Count

Mammals balance X-linked gene dosage by silencing one X chromosome in female cells, a process that begins with counting the number of X chromosomes. Recent reports suggest homologous X chromosome pairing may be a prerequisite for silencing, providing a basis for counting by ensuring that silencing o...

Full description

Saved in:
Bibliographic Details
Published in:Current biology 2008-03, Vol.18 (6), p.R255-R256
Main Authors: Royce-Tolland, Morgan, Panning, Barbara
Format: Article
Language:English
Subjects:
Animals
Female
RNA, Long Noncoding
RNA, Untranslated - genetics
X Chromosome - genetics
X Chromosome - metabolism
X Chromosome Inactivation - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mammals balance X-linked gene dosage by silencing one X chromosome in female cells, a process that begins with counting the number of X chromosomes. Recent reports suggest homologous X chromosome pairing may be a prerequisite for silencing, providing a basis for counting by ensuring that silencing only occurs in cells with two X chromosomes.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2008.01.039