A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor

ABO blood groups greatly influence circulating von Willebrand factor (VWF) levels, and O group subjects have lower VWF values. In this study, we investigated whether ABO groups affect VWF survival by monitoring the post-DDAVP (1-desamino-8-d arginine vasopressin) time courses of VWF antigen (VWF:Ag)...

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Published in:Blood 2008-04, Vol.111 (7), p.3540-3545
Main Authors: Gallinaro, Lisa, Cattini, Maria Grazia, Sztukowska, Maryta, Padrini, Roberto, Sartorello, Francesca, Pontara, Elena, Bertomoro, Antonella, Daidone, Viviana, Pagnan, Antonio, Casonato, Alessandra
Format: Article
Language:English
Subjects:
ABO Blood-Group System - blood
Biological and medical sciences
Collagen - metabolism
Deamino Arginine Vasopressin - administration & dosage
Endothelial Cells - metabolism
Female
Half-Life
Hematologic and hematopoietic diseases
Hemostatics - administration & dosage
Humans
Male
Medical sciences
Protein Binding - drug effects
von Willebrand Factor - analysis
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Summary:ABO blood groups greatly influence circulating von Willebrand factor (VWF) levels, and O group subjects have lower VWF values. In this study, we investigated whether ABO groups affect VWF survival by monitoring the post-DDAVP (1-desamino-8-d arginine vasopressin) time courses of VWF antigen (VWF:Ag), VWF collagen binding (VWF:CB), and factor VIII (FVIII) in 47 healthy subjects (28 O and 19 non-O blood groups). The elimination half-life (T1/2el) of VWF was found significantly shorter in O than in non-O subjects (10.0 ± 0.8 hours vs 25.5 ± 5.3 hours, respectively; P < .01), as was the T1/2el of VWF:CB (7.9 ± 0.5 hours vs 20.9 ± 4.5 hours; P < .01). A direct linear correlation was found between basal VWF:Ag and T1/2el, subjects with higher VWF levels having longer-surviving VWF. ABO blood groups appeared to strongly influence VWF clearance, but not its synthesis or release from endothelial cells. The VWF propeptide to VWF:Ag ratio, useful for predicting an increased VWF clearance, was found significantly higher in O than in non-O individuals (1.6 ± 0.1 vs 1.2 ± 0.5, P < .001), with values that correlated inversely with T1/2el (P < .001). Based on these findings, we conclude that the lower VWF values in O group individuals is attributable to a shorter VWF survival and circulating VWF values are strongly influenced by its half-life.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2007-11-122945