Biomechanical, microvascular, and cellular factors promote muscle and bone regeneration

It is becoming clear that the long-term outcome of complex bone injuries benefits from approaches that selectively target biomechanical, vascular, and cellular pathways. The typically held view of either biological or mechanical aspects of healing is oversimplified and does not correspond to clinica...

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Bibliographic Details
Published in:Exercise and sport sciences reviews 2008-04, Vol.36 (2), p.64-70
Main Authors: Duda, Georg N, Taylor, William R, Winkler, Tobias, Matziolis, Georg, Heller, Markus O, Haas, Norbert P, Perka, Carsten, Schaser, Klaus-D
Format: Article
Language:English
Subjects:
Animals
Biomechanical Phenomena
Bone Regeneration - physiology
Collateral Circulation - physiology
Exercise - physiology
Femur - physiopathology
Fractures, Bone - metabolism
Humans
Microcirculation - physiology
Muscle, Skeletal - blood supply
Muscle, Skeletal - physiology
Periosteum - physiology
Walking - physiology
Wound Healing - physiology
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Summary:It is becoming clear that the long-term outcome of complex bone injuries benefits from approaches that selectively target biomechanical, vascular, and cellular pathways. The typically held view of either biological or mechanical aspects of healing is oversimplified and does not correspond to clinical reality. The fundamental mechanisms of soft tissue regeneration most likely hold the key to understanding healing response.
ISSN:0091-6331
DOI:10.1097/JES.0b013e318168eb88