Carbamidocyclophanes A−E, Chlorinated Paracyclophanes with Cytotoxic and Antibiotic Activity from the Vietnamese Cyanobacterium Nostoc sp

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2007-04, Vol.70 (4), p.499-503
• Main Authors: Bui, Ha T. N, Jansen, Rolf, Pham, Hang T. L, Mundt, Sabine
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Applied microbiology; Biological and medical sciences; Chemotherapic agents; Cyanophyta; Drug Screening Assays, Antitumor; Female; Fundamental and applied biological sciences. Psychology; Humans; Hydrocarbons, Chlorinated - chemistry; Hydrocarbons, Chlorinated - isolation & purification; Hydrocarbons, Chlorinated - pharmacology; Microbial Sensitivity Tests; Microbiology; Molecular Structure; Nostoc; Nostoc - chemistry; Polycyclic Compounds - chemistry; Polycyclic Compounds - isolation & purification; Polycyclic Compounds - pharmacology; Staphylococcus aureus; Staphylococcus aureus - drug effects; Tumor Cells, Cultured; Vietnam
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np060324m

Five new paracyclophanes, carbamidocyclophanes A−E (1−5), characterized by carbamido side chains at a symmetric [7.7]paracyclophane ring, have been isolated from the biomass of the Vietnamese Nostoc sp. CAVN 10. Structure elucidation by spectroscopic methods showed that 1−5 vary in the substitution pattern of the chlorinated butyl side chains. The compounds exhibited cytotoxic activity against MCF-7 (breast cancer cell line) and Fl cells (human amniotic epithelial cell line) and moderate antibacterial activity against the Gram-positive bacterium Staphylococcus aureus.