Furanocembranoids from the Stem Bark of Croton oblongifolius

Four novel furanocembranoids (1−4) were isolated from the stem bark of Croton oblongifolius. Their structures were elucidated on the basis of spectroscopic analysis, mainly NMR and MS. Compounds 1, 3, and 4 exhibited good cytotoxicity against several human tumor cell lines.

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-04, Vol.70 (4), p.659-661
Main Authors: Pudhom, Khanitha, Vilaivan, Tirayut, Ngamrojanavanich, Nattaya, Dechangvipart, Suchon, Sommit, Damrong, Petsom, Amorn, Roengsumran, Sophon
Format: Article
Language:English
Subjects:
anticarcinogenic activity
Antineoplastic agents
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
chemical structure
Croton
Croton - chemistry
Croton oblongifolius
cultured cells
cytotoxicity
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
diterpenoids
Drug Screening Assays, Antitumor
Euphorbiaceae
furanocembranoid
General aspects
General pharmacology
Humans
Medical sciences
medicinal plants
medicinal properties
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oriental traditional medicine
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
Plant Bark - chemistry
Plants, Medicinal - chemistry
spectral analysis
stereochemistry
Thailand
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Description
Summary:Four novel furanocembranoids (1−4) were isolated from the stem bark of Croton oblongifolius. Their structures were elucidated on the basis of spectroscopic analysis, mainly NMR and MS. Compounds 1, 3, and 4 exhibited good cytotoxicity against several human tumor cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np060520t