Assessment of health-related quality of life of adolescent cancer patients using the Minneapolis-Manchester Quality of Life Adolescent Questionnaire

Background Improved survival after childhood cancer has shifted the focus to health‐related quality of life (HRQL)—an understudied problem, especially among adolescents. Procedure We assessed HRQL among adolescents utilizing a validated self‐report tool, the Minneapolis‐Manchester Quality of Life (M...

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Published in:Pediatric blood & cancer 2007-06, Vol.48 (7), p.678-686
Main Authors: Wu, Eric, Robison, Leslie L., Jenney, Meriel E.M., Rockwood, Todd H., Feusner, James, Friedman, Debra, Kane, Robert L., Bhatia, Smita
Format: Article
Language:English
Subjects:
Adolescent
adolescents
Adult
cancer survivors
Cross-Sectional Studies
Female
Humans
Male
Multivariate Analysis
Neoplasms - diagnosis
Neoplasms - psychology
Neoplasms - therapy
QoL
Quality of Life
Sickness Impact Profile
Surveys and Questionnaires
United States
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cited_by cdi_FETCH-LOGICAL-c3964-dd4b4c9a453863cbc913fa59c06ca4d63a7502c22b53173e9b3f6b86b02d75bf3
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container_issue 7
container_start_page 678
container_title Pediatric blood & cancer
container_volume 48
creator Wu, Eric
Robison, Leslie L.
Jenney, Meriel E.M.
Rockwood, Todd H.
Feusner, James
Friedman, Debra
Kane, Robert L.
Bhatia, Smita
description Background Improved survival after childhood cancer has shifted the focus to health‐related quality of life (HRQL)—an understudied problem, especially among adolescents. Procedure We assessed HRQL among adolescents utilizing a validated self‐report tool, the Minneapolis‐Manchester Quality of Life (MMQL) Adolescent Form, consisting of 46 items comprising seven domains: physical, cognitive, psychological and social functioning, body image, intimate relations, and outlook on life, and computed an overall QoL score. The MMQL Adolescent Form was administered to 226 adolescent survivors of childhood cancer a median of 7.8 years from diagnosis (off therapy—median age: 16.2 years), 136 adolescent cancer patients undergoing therapy (on therapy—median age: 16.4 years), and 134 healthy adolescents (controls—median age: 15.5 years). Primary diagnoses included leukemia (46%), lymphoma (26%), brain tumors (5%), and other solid tumors (23%). Results Compared to healthy controls, on‐therapy patients were at increased risk for reporting poor overall QoL [Odds Ratio (OR) = 3.3, P = 0.002)] and poor physical functioning (OR = 11.8, P 
doi_str_mv 10.1002/pbc.20874
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Procedure We assessed HRQL among adolescents utilizing a validated self‐report tool, the Minneapolis‐Manchester Quality of Life (MMQL) Adolescent Form, consisting of 46 items comprising seven domains: physical, cognitive, psychological and social functioning, body image, intimate relations, and outlook on life, and computed an overall QoL score. The MMQL Adolescent Form was administered to 226 adolescent survivors of childhood cancer a median of 7.8 years from diagnosis (off therapy—median age: 16.2 years), 136 adolescent cancer patients undergoing therapy (on therapy—median age: 16.4 years), and 134 healthy adolescents (controls—median age: 15.5 years). Primary diagnoses included leukemia (46%), lymphoma (26%), brain tumors (5%), and other solid tumors (23%). Results Compared to healthy controls, on‐therapy patients were at increased risk for reporting poor overall QoL [Odds Ratio (OR) = 3.3, P = 0.002)] and poor physical functioning (OR = 11.8, P &lt; 0.001). Off‐therapy survivors did not differ significantly from healthy controls for overall QoL (OR = 1.6, P = 0.5) or any HRQL domains. Female patients, both on‐ and off‐therapy, were more likely to report poorer overall QoL, physical, psychological and cognitive functioning as well as poorer body image when compared with male patients. Conclusions While adolescent cancer patients undergoing active therapy report poor physical functioning, there is no evidence of long‐term QoL sequelae. Pediatr Blood Cancer 2007;48:678–686. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.20874</identifier><identifier>PMID: 16628553</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; adolescents ; Adult ; cancer survivors ; Cross-Sectional Studies ; Female ; Humans ; Male ; Multivariate Analysis ; Neoplasms - diagnosis ; Neoplasms - psychology ; Neoplasms - therapy ; QoL ; Quality of Life ; Sickness Impact Profile ; Surveys and Questionnaires ; United States</subject><ispartof>Pediatric blood &amp; cancer, 2007-06, Vol.48 (7), p.678-686</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>(c) 2006 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3964-dd4b4c9a453863cbc913fa59c06ca4d63a7502c22b53173e9b3f6b86b02d75bf3</citedby><cites>FETCH-LOGICAL-c3964-dd4b4c9a453863cbc913fa59c06ca4d63a7502c22b53173e9b3f6b86b02d75bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16628553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Eric</creatorcontrib><creatorcontrib>Robison, Leslie L.</creatorcontrib><creatorcontrib>Jenney, Meriel E.M.</creatorcontrib><creatorcontrib>Rockwood, Todd H.</creatorcontrib><creatorcontrib>Feusner, James</creatorcontrib><creatorcontrib>Friedman, Debra</creatorcontrib><creatorcontrib>Kane, Robert L.</creatorcontrib><creatorcontrib>Bhatia, Smita</creatorcontrib><title>Assessment of health-related quality of life of adolescent cancer patients using the Minneapolis-Manchester Quality of Life Adolescent Questionnaire</title><title>Pediatric blood &amp; cancer</title><addtitle>Pediatr. Blood Cancer</addtitle><description>Background Improved survival after childhood cancer has shifted the focus to health‐related quality of life (HRQL)—an understudied problem, especially among adolescents. Procedure We assessed HRQL among adolescents utilizing a validated self‐report tool, the Minneapolis‐Manchester Quality of Life (MMQL) Adolescent Form, consisting of 46 items comprising seven domains: physical, cognitive, psychological and social functioning, body image, intimate relations, and outlook on life, and computed an overall QoL score. The MMQL Adolescent Form was administered to 226 adolescent survivors of childhood cancer a median of 7.8 years from diagnosis (off therapy—median age: 16.2 years), 136 adolescent cancer patients undergoing therapy (on therapy—median age: 16.4 years), and 134 healthy adolescents (controls—median age: 15.5 years). Primary diagnoses included leukemia (46%), lymphoma (26%), brain tumors (5%), and other solid tumors (23%). Results Compared to healthy controls, on‐therapy patients were at increased risk for reporting poor overall QoL [Odds Ratio (OR) = 3.3, P = 0.002)] and poor physical functioning (OR = 11.8, P &lt; 0.001). Off‐therapy survivors did not differ significantly from healthy controls for overall QoL (OR = 1.6, P = 0.5) or any HRQL domains. Female patients, both on‐ and off‐therapy, were more likely to report poorer overall QoL, physical, psychological and cognitive functioning as well as poorer body image when compared with male patients. Conclusions While adolescent cancer patients undergoing active therapy report poor physical functioning, there is no evidence of long‐term QoL sequelae. Pediatr Blood Cancer 2007;48:678–686. © 2006 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>adolescents</subject><subject>Adult</subject><subject>cancer survivors</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - psychology</subject><subject>Neoplasms - therapy</subject><subject>QoL</subject><subject>Quality of Life</subject><subject>Sickness Impact Profile</subject><subject>Surveys and Questionnaires</subject><subject>United States</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp1kUFP2zAUx60JNBjswBdAOSHtEGrHsZMcS8UKot1WAUPiYtnOy-rhJsFONPo9-MA4a0dPOz1b7_d-enp_hE4IPicYJ6NW6fME51n6AR0SlrKYYZLtvb9xcYA-ef87oByz_CM6IJwnOWP0EL2OvQfvV1B3UVNFS5C2W8YOrOygjJ57aU23HjrWVDBUWTYWvB54LWsNLmplZ8LXR7039a-oW0I0N3UNsm2s8fE8UEvwXSAXO91s0I13rkUfENPUtTQOjtF-Ja2Hz9t6hO6_Xt5NruLZ9-n1ZDyLNS14GpdlqlJdyJTRnFOtdEFoJVmhMdcyLTmVGcOJThLFKMkoFIpWXOVc4aTMmKroETrbeFvXPA8LiJUJ61gra2h6LzKcUpKzIoBfNqB2jfcOKtE6s5JuLQgWQwQiRCD-RhDY0620Vysod-T25gEYbYA_xsL6_ybx42LyTxlvJkw448v7hHRPgmc0Y-Lh21TcTm8Wt493V-InfQMobaLt</recordid><startdate>20070615</startdate><enddate>20070615</enddate><creator>Wu, Eric</creator><creator>Robison, Leslie L.</creator><creator>Jenney, Meriel E.M.</creator><creator>Rockwood, Todd H.</creator><creator>Feusner, James</creator><creator>Friedman, Debra</creator><creator>Kane, Robert L.</creator><creator>Bhatia, Smita</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070615</creationdate><title>Assessment of health-related quality of life of adolescent cancer patients using the Minneapolis-Manchester Quality of Life Adolescent Questionnaire</title><author>Wu, Eric ; Robison, Leslie L. ; Jenney, Meriel E.M. ; Rockwood, Todd H. ; Feusner, James ; Friedman, Debra ; Kane, Robert L. ; Bhatia, Smita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3964-dd4b4c9a453863cbc913fa59c06ca4d63a7502c22b53173e9b3f6b86b02d75bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>adolescents</topic><topic>Adult</topic><topic>cancer survivors</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - psychology</topic><topic>Neoplasms - therapy</topic><topic>QoL</topic><topic>Quality of Life</topic><topic>Sickness Impact Profile</topic><topic>Surveys and Questionnaires</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Eric</creatorcontrib><creatorcontrib>Robison, Leslie L.</creatorcontrib><creatorcontrib>Jenney, Meriel E.M.</creatorcontrib><creatorcontrib>Rockwood, Todd H.</creatorcontrib><creatorcontrib>Feusner, James</creatorcontrib><creatorcontrib>Friedman, Debra</creatorcontrib><creatorcontrib>Kane, Robert L.</creatorcontrib><creatorcontrib>Bhatia, Smita</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric blood &amp; cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Eric</au><au>Robison, Leslie L.</au><au>Jenney, Meriel E.M.</au><au>Rockwood, Todd H.</au><au>Feusner, James</au><au>Friedman, Debra</au><au>Kane, Robert L.</au><au>Bhatia, Smita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of health-related quality of life of adolescent cancer patients using the Minneapolis-Manchester Quality of Life Adolescent Questionnaire</atitle><jtitle>Pediatric blood &amp; cancer</jtitle><addtitle>Pediatr. Blood Cancer</addtitle><date>2007-06-15</date><risdate>2007</risdate><volume>48</volume><issue>7</issue><spage>678</spage><epage>686</epage><pages>678-686</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>Background Improved survival after childhood cancer has shifted the focus to health‐related quality of life (HRQL)—an understudied problem, especially among adolescents. Procedure We assessed HRQL among adolescents utilizing a validated self‐report tool, the Minneapolis‐Manchester Quality of Life (MMQL) Adolescent Form, consisting of 46 items comprising seven domains: physical, cognitive, psychological and social functioning, body image, intimate relations, and outlook on life, and computed an overall QoL score. The MMQL Adolescent Form was administered to 226 adolescent survivors of childhood cancer a median of 7.8 years from diagnosis (off therapy—median age: 16.2 years), 136 adolescent cancer patients undergoing therapy (on therapy—median age: 16.4 years), and 134 healthy adolescents (controls—median age: 15.5 years). Primary diagnoses included leukemia (46%), lymphoma (26%), brain tumors (5%), and other solid tumors (23%). Results Compared to healthy controls, on‐therapy patients were at increased risk for reporting poor overall QoL [Odds Ratio (OR) = 3.3, P = 0.002)] and poor physical functioning (OR = 11.8, P &lt; 0.001). Off‐therapy survivors did not differ significantly from healthy controls for overall QoL (OR = 1.6, P = 0.5) or any HRQL domains. Female patients, both on‐ and off‐therapy, were more likely to report poorer overall QoL, physical, psychological and cognitive functioning as well as poorer body image when compared with male patients. Conclusions While adolescent cancer patients undergoing active therapy report poor physical functioning, there is no evidence of long‐term QoL sequelae. Pediatr Blood Cancer 2007;48:678–686. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16628553</pmid><doi>10.1002/pbc.20874</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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source Wiley-Blackwell Read & Publish Collection
subjects Adolescent
adolescents
Adult
cancer survivors
Cross-Sectional Studies
Female
Humans
Male
Multivariate Analysis
Neoplasms - diagnosis
Neoplasms - psychology
Neoplasms - therapy
QoL
Quality of Life
Sickness Impact Profile
Surveys and Questionnaires
United States
title Assessment of health-related quality of life of adolescent cancer patients using the Minneapolis-Manchester Quality of Life Adolescent Questionnaire
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