Genomics and gene transcription kinetics in yeast

As an adaptive response to new conditions, mRNA concentrations in eukaryotes are readjusted after any environmental change. Although mRNA concentrations can be modified by altering synthesis and/or degradation rates, the rapidity of the transition to a new concentration depends on the regulation of...

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Bibliographic Details
Published in:Trends in genetics 2007-05, Vol.23 (5), p.250-257
Main Authors: Pérez-Ortín, José E, Alepuz, Paula M, Moreno, Joaquín
Format: Article
Language:English
Subjects:
Biological and medical sciences
Forecasting
Fundamental and applied biological sciences. Psychology
Gene Expression
gene expression regulation
genes
Genetics of eukaryotes. Biological and molecular evolution
genomics
Genomics - methods
Kinetics
literature reviews
Medical Education
messenger RNA
Models, Genetic
Molecular and cellular biology
Molecular genetics
RNA, Messenger - metabolism
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
transcription (genetics)
Transcription, Genetic
Transcription. Transcription factor. Splicing. Rna processing
yeasts
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Summary:As an adaptive response to new conditions, mRNA concentrations in eukaryotes are readjusted after any environmental change. Although mRNA concentrations can be modified by altering synthesis and/or degradation rates, the rapidity of the transition to a new concentration depends on the regulation of mRNA stability. There are several plausible transcriptional strategies following environmental change, reflecting different degrees of compromise between speed of response and cost of synthesis. The recent development of genomic techniques now enables researchers to determine simultaneously (either directly or indirectly) the transcription rates and mRNA half-lifes, together with mRNA concentrations, corresponding to all yeast genes. Such experiments could provide a new picture of the transcriptional response, by enabling us to characterize the kinetic strategies that are used by different genes under given environmental conditions.
ISSN:0168-9525
DOI:10.1016/j.tig.2007.03.006