Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats

To study the repair of bone defect filled with autograft or bovine bone devitalized matrix in rats under anti-inflammatory action. Two hundred and forty Wistar rats were distributed to two groups of 120 animals each. A 2mm-diameter defect was created in the femoral diaphysis. Animals of Group I had...

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Bibliographic Details
Published in:Acta cirúrgica brasileira 2008-03, Vol.23 (2), p.140-148
Main Authors: Silva, Roberto Antoniolli da, Fagundes, Djalma José, Antoniolli Silva, Andréia Conceição Milan Brochado, Sisti, Karin Ellen, Brochado de Carvalho, Themis Maria Milan, Silva, Daniel Nunes e
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Bone Transplantation
Cattle
Dexamethasone - pharmacology
Diclofenac - pharmacology
Male
Osseointegration - drug effects
Rats
Rats, Wistar
Thiazines - pharmacology
Thiazoles - pharmacology
Time Factors
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Summary:To study the repair of bone defect filled with autograft or bovine bone devitalized matrix in rats under anti-inflammatory action. Two hundred and forty Wistar rats were distributed to two groups of 120 animals each. A 2mm-diameter defect was created in the femoral diaphysis. Animals of Group I had the bone defect filled with autograft and those of Group II, with bovine bone devitalized matrix. Animals of each group were redistributed to four subgroups according to the intramuscular administration of anti-inflammatory drug or saline solution: A - diclofenac sodium; B - dexamethasone; C - meloxicam; D - saline solution. Evaluation periods were 7, 14 and 30 days. Histological evaluation consisted of quantifying the inflammatory process, the bone neoformation, the collagen formation and the presence of macrophages. Animals of Group I did not show significant difference considering inflammatory reaction. Significant and progressive increase of bone neoformation was observed in both groups. The animals that received meloxicam and autograft showed less collagen formation at 14 and 30 days. The number of macrophages was higher in Group II than in Group I. The animals treated with dexamethasone and saline solution did not show statistically significant difference. Diclofenac sodium and meloxicam delayed bone graft repair and dexamethasone did not interfere in it.
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-86502008000200006