EPSP depression following neocortical seizures in cat

Summary To study the possible mechanism(s) underlying unresponsiveness following neocortical seizures, we recorded excitatory postsynaptic potentials (EPSPs) of cortical neurons evoked by ipsilateral cortical stimulation before and after spontaneous or elicited seizures. Regular‐spiking neurons (n =...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) 2008-04, Vol.49 (4), p.705-709
Main Authors: Nita, Dragos A., Cissé, Youssouf, Timofeev, Igor
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Cats
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Disease Models, Animal
EEG
Electric Stimulation - methods
Electrodes, Implanted
Electroencephalography - statistics & numerical data
Epilepsy - pathology
Epilepsy - physiopathology
Evoked Potentials - physiology
Excitatory Postsynaptic Potentials - physiology
Functional Laterality - physiology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Intracellular recordings
Medical sciences
Microelectrodes
Neocortex
Neocortex - cytology
Neocortex - pathology
Neocortex - physiopathology
Nervous system (semeiology, syndromes)
Neurology
Neurons - pathology
Neurons - physiology
Neuropharmacology
Patch-Clamp Techniques
Pharmacology. Drug treatments
Seizures
Seizures - etiology
Seizures - pathology
Seizures - physiopathology
Synaptic responsiveness
Synaptic Transmission - physiology
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Summary:Summary To study the possible mechanism(s) underlying unresponsiveness following neocortical seizures, we recorded excitatory postsynaptic potentials (EPSPs) of cortical neurons evoked by ipsilateral cortical stimulation before and after spontaneous or elicited seizures. Regular‐spiking neurons (n = 32) were intracellularly recorded in association area five of cats under ketamine–xylazine or barbiturate anesthesia. Compared with control responses, cortically evoked EPSPs were characterized by decreased amplitude after electrographic seizures. Synaptic responses and intrinsic properties were measured by applying extracellular electrical stimuli followed by intracellular hyperpolarizing current pulses. The input resistance decreased during seizures but quickly recovered to control level after the paroxysms, whereas the amplitude of evoked EPSPs remained lower following seizures, generally for 2–12 min, suggesting that the decreased EPSPs were not due to an alteration of intrinsic response. Data demonstrate a long‐lasting decreased synaptic responsiveness following generalized spike‐wave seizures slowly recovering in time.
ISSN:0013-9580
1528-1167
DOI:10.1111/j.1528-1167.2007.01431.x