High Blood Pressure and Cardiovascular Disease Mortality Risk Among U.S. Adults: The Third National Health and Nutrition Examination Survey Mortality Follow-up Study

Purpose We sought to examine whether prehypertension is associated with increased cardiovascular disease (CVD) mortality risk and whether the association of blood pressure with CVD outcome is modified by social demographics or hypertension treatment and control. Methods Data from the Third National...

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Bibliographic Details
Published in:Annals of epidemiology 2008-04, Vol.18 (4), p.302-309
Main Authors: Gu, Qiuping, PhD, Burt, Vicki L., SCM, Paulose-Ram, Ryne, PhD, Yoon, Sarah, PhD, Gillum, Richard F., MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
African Americans
Age Factors
Aged
Blood Pressure
Cardiovascular Disease
Cardiovascular Diseases - ethnology
Cardiovascular Diseases - mortality
Female
Humans
Hypertension
Hypertension - drug therapy
Hypertension - epidemiology
Hypertension - ethnology
Hypertension - physiopathology
Internal Medicine
Male
Middle Aged
Mortality
NHANES
Nutrition Surveys
Risk Assessment
United States - epidemiology
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Summary:Purpose We sought to examine whether prehypertension is associated with increased cardiovascular disease (CVD) mortality risk and whether the association of blood pressure with CVD outcome is modified by social demographics or hypertension treatment and control. Methods Data from the Third National Health and Nutrition Examination Survey and mortality follow-up through 2000 were used to estimate the relative risk of death from CVD associated with hypertension and prehypertension, after adjusting for confounding and modifying factors. Results Compared with normotension, the relative risks of CVD mortality were 1.23 (95% confidence interval [95% CI] 0.85–1.79, p = 0.26) for prehypertension, 1.64 (95% CI 1.11–2.41, p = 0.01) for hypertension, 1.74 (95% CI 1.28–2.49, p = 0.007) for uncontrolled hypertension, and 1.15 (95% CI 0.79–1.80, p  = 0.53) for controlled hypertension. Hypertensive adults
ISSN:1047-2797
1873-2585
DOI:10.1016/j.annepidem.2007.11.013