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Preliminary Findings of External Counterpulsation for Ischemic Stroke Patient With Large Artery Occlusive Disease
We aimed to investigate the feasibility and therapeutic effect of external counterpulsation (ECP) in ischemic stroke. The trial was a randomized, crossover, assessment-blinded, proof-of-concept trial. ECP treatment consisted of 35 daily 1-hour sessions. Patients were randomized to either early (ECP...
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| Published in: | Stroke (1970) 2008-04, Vol.39 (4), p.1340-1343 |
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| container_end_page | 1343 |
| container_issue | 4 |
| container_start_page | 1340 |
| container_title | Stroke (1970) |
| container_volume | 39 |
| creator | JING HAO HAN LEUNG, Thomas W LAM, Wynnie W SOO, Yannie O ALEXANDROV, Anne W MOK, Vincent LEUNG, Yee-Fong V LO, Raymond KA SING WONG |
| description | We aimed to investigate the feasibility and therapeutic effect of external counterpulsation (ECP) in ischemic stroke.
The trial was a randomized, crossover, assessment-blinded, proof-of-concept trial. ECP treatment consisted of 35 daily 1-hour sessions. Patients were randomized to either early (ECP weeks 1 to 7 and no ECP weeks 8 to 14) or late group (no ECP weeks 1 to 7 and ECP weeks 8 to 14). Primary outcomes were an overall change in National Institutes of Health Stroke Scale (NIHSS) and cerebral blood flow estimated by color velocity imaging quantification. Secondary outcomes were change in NIHSS, color velocity imaging quantification, favorable functional outcome (modified Rankin scale, 0 to 2), and stroke recurrence at weeks 7 and 14, respectively.
Fifty patients were recruited. At week 7, there was a significant change in NIHSS (early 3.5 vs late 1.9; P=0.042). After adjusting for treatment sequence, ECP was associated with a favorable trend of change in NIHSS of 2.1 vs 1.3 for non-ECP (P=0.061). Changes of color velocity imaging quantification were not significant but tended to increase with ECP. At week 14, a favorable functional outcome was found in 100% of early group patients compared to 76% in the late group (P=0.022).
ECP is feasible for ischemic stroke patients with larger artery disease. |
| doi_str_mv | 10.1161/STROKEAHA.107.500132 |
| format | article |
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The trial was a randomized, crossover, assessment-blinded, proof-of-concept trial. ECP treatment consisted of 35 daily 1-hour sessions. Patients were randomized to either early (ECP weeks 1 to 7 and no ECP weeks 8 to 14) or late group (no ECP weeks 1 to 7 and ECP weeks 8 to 14). Primary outcomes were an overall change in National Institutes of Health Stroke Scale (NIHSS) and cerebral blood flow estimated by color velocity imaging quantification. Secondary outcomes were change in NIHSS, color velocity imaging quantification, favorable functional outcome (modified Rankin scale, 0 to 2), and stroke recurrence at weeks 7 and 14, respectively.
Fifty patients were recruited. At week 7, there was a significant change in NIHSS (early 3.5 vs late 1.9; P=0.042). After adjusting for treatment sequence, ECP was associated with a favorable trend of change in NIHSS of 2.1 vs 1.3 for non-ECP (P=0.061). Changes of color velocity imaging quantification were not significant but tended to increase with ECP. At week 14, a favorable functional outcome was found in 100% of early group patients compared to 76% in the late group (P=0.022).
ECP is feasible for ischemic stroke patients with larger artery disease.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.107.500132</identifier><identifier>PMID: 18309160</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Biological and medical sciences ; Blood Pressure ; Brain Ischemia - diagnostic imaging ; Brain Ischemia - physiopathology ; Brain Ischemia - therapy ; Carotid Arteries - diagnostic imaging ; Carotid Arteries - physiology ; Cerebrovascular Circulation ; Counterpulsation - adverse effects ; Cross-Over Studies ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Pilot Projects ; Stroke - diagnostic imaging ; Stroke - physiopathology ; Stroke - therapy ; Treatment Outcome ; Ultrasonography, Doppler, Transcranial ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2008-04, Vol.39 (4), p.1340-1343</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-8a970c2efd6c1bd2cf888bac7905a9135c6178ebc45d51b97a589848d2da2793</citedby><cites>FETCH-LOGICAL-c448t-8a970c2efd6c1bd2cf888bac7905a9135c6178ebc45d51b97a589848d2da2793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20214843$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18309160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JING HAO HAN</creatorcontrib><creatorcontrib>LEUNG, Thomas W</creatorcontrib><creatorcontrib>LAM, Wynnie W</creatorcontrib><creatorcontrib>SOO, Yannie O</creatorcontrib><creatorcontrib>ALEXANDROV, Anne W</creatorcontrib><creatorcontrib>MOK, Vincent</creatorcontrib><creatorcontrib>LEUNG, Yee-Fong V</creatorcontrib><creatorcontrib>LO, Raymond</creatorcontrib><creatorcontrib>KA SING WONG</creatorcontrib><title>Preliminary Findings of External Counterpulsation for Ischemic Stroke Patient With Large Artery Occlusive Disease</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>We aimed to investigate the feasibility and therapeutic effect of external counterpulsation (ECP) in ischemic stroke.
The trial was a randomized, crossover, assessment-blinded, proof-of-concept trial. ECP treatment consisted of 35 daily 1-hour sessions. Patients were randomized to either early (ECP weeks 1 to 7 and no ECP weeks 8 to 14) or late group (no ECP weeks 1 to 7 and ECP weeks 8 to 14). Primary outcomes were an overall change in National Institutes of Health Stroke Scale (NIHSS) and cerebral blood flow estimated by color velocity imaging quantification. Secondary outcomes were change in NIHSS, color velocity imaging quantification, favorable functional outcome (modified Rankin scale, 0 to 2), and stroke recurrence at weeks 7 and 14, respectively.
Fifty patients were recruited. At week 7, there was a significant change in NIHSS (early 3.5 vs late 1.9; P=0.042). After adjusting for treatment sequence, ECP was associated with a favorable trend of change in NIHSS of 2.1 vs 1.3 for non-ECP (P=0.061). Changes of color velocity imaging quantification were not significant but tended to increase with ECP. At week 14, a favorable functional outcome was found in 100% of early group patients compared to 76% in the late group (P=0.022).
ECP is feasible for ischemic stroke patients with larger artery disease.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Brain Ischemia - diagnostic imaging</subject><subject>Brain Ischemia - physiopathology</subject><subject>Brain Ischemia - therapy</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Arteries - physiology</subject><subject>Cerebrovascular Circulation</subject><subject>Counterpulsation - adverse effects</subject><subject>Cross-Over Studies</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Pilot Projects</subject><subject>Stroke - diagnostic imaging</subject><subject>Stroke - physiopathology</subject><subject>Stroke - therapy</subject><subject>Treatment Outcome</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EokvhHyDkC9yyjL9i-7hath9ipa3oShwjx5m0hsTZ2gmi_76pdlWOnMYaP-97mIeQjwyWjJXs6-3-x-77ZnW1WjLQSwXABH9FFkxxWciSm9dkASBswaW1Z-Rdzr8AgAuj3pIzZgRYVsKCPNwk7EIfokuP9CLEJsS7TIeWbv6OmKLr6HqY4vw8TF12YxgibYdEr7O_xz54ejum4TfSm_kL40h_hvGebl26Q7pKc-qR7rzvphz-IP0WMrqM78mb1nUZP5zmOdlfbPbrq2K7u7xer7aFl9KMhXFWg-fYNqVndcN9a4ypndcWlLNMKF8ybbD2UjWK1VY7ZayRpuGN49qKc_LlWHtIw8OEeaz6kD12nYs4TLnSIIWSQv8X5FAqLdhzozyCPg05J2yrQwr9fLeKQfWspHpRMm90dVQyxz6d-qe6x-Zf6ORgBj6fAJe969rkog_5hePAmTRSiCdDDJZS</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>JING HAO HAN</creator><creator>LEUNG, Thomas W</creator><creator>LAM, Wynnie W</creator><creator>SOO, Yannie O</creator><creator>ALEXANDROV, Anne W</creator><creator>MOK, Vincent</creator><creator>LEUNG, Yee-Fong V</creator><creator>LO, Raymond</creator><creator>KA SING WONG</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Preliminary Findings of External Counterpulsation for Ischemic Stroke Patient With Large Artery Occlusive Disease</title><author>JING HAO HAN ; LEUNG, Thomas W ; LAM, Wynnie W ; SOO, Yannie O ; ALEXANDROV, Anne W ; MOK, Vincent ; LEUNG, Yee-Fong V ; LO, Raymond ; KA SING WONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-8a970c2efd6c1bd2cf888bac7905a9135c6178ebc45d51b97a589848d2da2793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Brain Ischemia - diagnostic imaging</topic><topic>Brain Ischemia - physiopathology</topic><topic>Brain Ischemia - therapy</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Arteries - physiology</topic><topic>Cerebrovascular Circulation</topic><topic>Counterpulsation - adverse effects</topic><topic>Cross-Over Studies</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Pilot Projects</topic><topic>Stroke - diagnostic imaging</topic><topic>Stroke - physiopathology</topic><topic>Stroke - therapy</topic><topic>Treatment Outcome</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JING HAO HAN</creatorcontrib><creatorcontrib>LEUNG, Thomas W</creatorcontrib><creatorcontrib>LAM, Wynnie W</creatorcontrib><creatorcontrib>SOO, Yannie O</creatorcontrib><creatorcontrib>ALEXANDROV, Anne W</creatorcontrib><creatorcontrib>MOK, Vincent</creatorcontrib><creatorcontrib>LEUNG, Yee-Fong V</creatorcontrib><creatorcontrib>LO, Raymond</creatorcontrib><creatorcontrib>KA SING WONG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JING HAO HAN</au><au>LEUNG, Thomas W</au><au>LAM, Wynnie W</au><au>SOO, Yannie O</au><au>ALEXANDROV, Anne W</au><au>MOK, Vincent</au><au>LEUNG, Yee-Fong V</au><au>LO, Raymond</au><au>KA SING WONG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary Findings of External Counterpulsation for Ischemic Stroke Patient With Large Artery Occlusive Disease</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>39</volume><issue>4</issue><spage>1340</spage><epage>1343</epage><pages>1340-1343</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>We aimed to investigate the feasibility and therapeutic effect of external counterpulsation (ECP) in ischemic stroke.
The trial was a randomized, crossover, assessment-blinded, proof-of-concept trial. ECP treatment consisted of 35 daily 1-hour sessions. Patients were randomized to either early (ECP weeks 1 to 7 and no ECP weeks 8 to 14) or late group (no ECP weeks 1 to 7 and ECP weeks 8 to 14). Primary outcomes were an overall change in National Institutes of Health Stroke Scale (NIHSS) and cerebral blood flow estimated by color velocity imaging quantification. Secondary outcomes were change in NIHSS, color velocity imaging quantification, favorable functional outcome (modified Rankin scale, 0 to 2), and stroke recurrence at weeks 7 and 14, respectively.
Fifty patients were recruited. At week 7, there was a significant change in NIHSS (early 3.5 vs late 1.9; P=0.042). After adjusting for treatment sequence, ECP was associated with a favorable trend of change in NIHSS of 2.1 vs 1.3 for non-ECP (P=0.061). Changes of color velocity imaging quantification were not significant but tended to increase with ECP. At week 14, a favorable functional outcome was found in 100% of early group patients compared to 76% in the late group (P=0.022).
ECP is feasible for ischemic stroke patients with larger artery disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>18309160</pmid><doi>10.1161/STROKEAHA.107.500132</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Stroke (1970), 2008-04, Vol.39 (4), p.1340-1343 |
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| source | Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Blood Pressure Brain Ischemia - diagnostic imaging Brain Ischemia - physiopathology Brain Ischemia - therapy Carotid Arteries - diagnostic imaging Carotid Arteries - physiology Cerebrovascular Circulation Counterpulsation - adverse effects Cross-Over Studies Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Pilot Projects Stroke - diagnostic imaging Stroke - physiopathology Stroke - therapy Treatment Outcome Ultrasonography, Doppler, Transcranial Vascular diseases and vascular malformations of the nervous system |
| title | Preliminary Findings of External Counterpulsation for Ischemic Stroke Patient With Large Artery Occlusive Disease |
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