SAA1 alpha/alpha alleles in Behçet's disease related amyloidosis

Behçet's disease (BD) related amyloidosis is relatively rare. Serum amyloid A protein (SAA) protein gene polymorphism is one of the factors implicated in the pathogenesis of AA type amyloidosis. The aim of this study is to investigate SAA1 gene polymorphism in different patient groups: (1) BD r...

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Bibliographic Details
Published in:Clinical rheumatology 2007-06, Vol.26 (6), p.927-929
Main Authors: Utku, Umut, Dilek, Melda, Akpolat, Ilkser, Bedir, Abdülkerim, Akpolat, Tekin
Format: Article
Language:English
Subjects:
Adult
Alleles
Amyloid
Amyloidosis
Amyloidosis - complications
Amyloidosis - genetics
Behcet Syndrome - complications
Behcet Syndrome - genetics
Behcet's syndrome
Case-Control Studies
Cohort Studies
Female
Gene polymorphism
Genes
Genotype
Genotype & phenotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Risk factors
Serum Amyloid A Protein - genetics
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Summary:Behçet's disease (BD) related amyloidosis is relatively rare. Serum amyloid A protein (SAA) protein gene polymorphism is one of the factors implicated in the pathogenesis of AA type amyloidosis. The aim of this study is to investigate SAA1 gene polymorphism in different patient groups: (1) BD related amyloidosis, (2) BD without amyloidosis, and (3) healthy controls. One hundred eleven patients from three main groups were included in the study: (1) BD related amyloidosis (n = 9), (2) BD without amyloidosis (n = 39), and (3) healthy controls (n = 63). Homozygous alpha/alpha is present in 78% of patients with BD and amyloidosis. The SAA1 alpha/alpha genotype is significantly more common among patients with BD and amyloidosis. This study demonstrated increased frequency of alpha/alpha genotype in BD related amyloidosis. To our knowledge, the relationship between alpha/alpha genotype and BD related amyloidosis was not studied previously. In conclusion, the SAA1 alpha/alpha genotype is a risk factor for amyloidosis in BD.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-006-0435-7