Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Abstract Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2 O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL- b -PMAA as a surfactant...

Full description

Saved in:
Bibliographic Details
Published in:Biomaterials 2008-06, Vol.29 (16), p.2548-2555
Main Authors: Yang, Jaemoon, Lim, Eun-Kyung, Lee, Hong Jae, Park, Joseph, Lee, Sang Cheon, Lee, Kwangyeol, Yoon, Ho-Geun, Suh, Jin-Suck, Huh, Yong-Min, Haam, Seungjoo
Format: Article
Language:English
Subjects:
Advanced Basic Science
Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Cancer
Cell Line, Tumor
Cetuximab
Dentistry
Epithelial Cells - pathology
Flow Cytometry
Fluorescence
Fluorescent Dyes
Humans
Magnetic nanoparticle
Magnetic Resonance Imaging
Microscopy, Fluorescence
Nanohybrid
Nanoparticles
Polyesters - chemical synthesis
Polymethacrylic Acids - chemical synthesis
Pyrenes - chemical synthesis
Receptor, Epidermal Growth Factor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2 O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL- b -PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2007.12.036