Perioperative Activin A Concentrations as a Predictive Marker of Neurologic Abnormalities in Children after Open Heart Surgery

Ischemic-reperfusion injury of the brain is a major adverse event after cardiac surgery, especially when extracorporeal circuits are used. Because brain injury induces local overproduction of activin A, we measured plasma concentrations in children after open heart surgery with cardiopulmonary bypas...

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Published in:Clinical chemistry (Baltimore, Md.) Md.), 2007-05, Vol.53 (5), p.982-985
Main Authors: Florio, Pasquale, Felipe Abella, Raul, de la Torre, Teresa, Giamberti, Alessandro, Luisi, Stefano, Butera, Gianfranco, Cazzaniga, Alessandro, Frigiola, Alessandro, Petraglia, Felice, Gazzolo, Diego
Format: Article
Language:English
Subjects:
Activins - blood
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Biomarkers - blood
Brain damage
Brain Diseases - etiology
Brain Diseases - prevention & control
Carbon dioxide
Cardiac Surgical Procedures - adverse effects
Cardiopulmonary Bypass - adverse effects
Case-Control Studies
Children & youth
Female
Fundamental and applied biological sciences. Psychology
Heart Defects, Congenital - surgery
Heart surgery
Humans
Hypoxia
Immunoassay
Infant
Infants
Intensive care
Intraoperative Care
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Nervous system
Patients
Plasma
Predictive Value of Tests
Reperfusion Injury - etiology
Reperfusion Injury - prevention & control
Risk factors
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Summary:Ischemic-reperfusion injury of the brain is a major adverse event after cardiac surgery, especially when extracorporeal circuits are used. Because brain injury induces local overproduction of activin A, we measured plasma concentrations in children after open heart surgery with cardiopulmonary bypass (CPB) to investigate the potential of measuring activin A for early identification of infants at risk for brain damage. We evaluated 45 infants (age
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2006.077149