Power spectral analysis of two-channel EEG in hypoxic–ischaemic encephalopathy

• Published in: Early human development 2007-06, Vol.83 (6), p.379-383
• Main Authors: Wong, Flora Y, Barfield, Charles P, Walker, Adrian M
• Format: Article
• Language: English
• Subjects: Advanced Basic Science; Analysis of Variance; Biological and medical sciences; Electroencephalography - methods; Embryology: invertebrates and vertebrates. Teratology; Fundamental and applied biological sciences. Psychology; Humans; Hypoxia-Ischemia, Brain - diagnosis; Infant, Newborn; Neonatal and Perinatal Medicine; Sleep - physiology; Spectrum Analysis - methods
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/j.earlhumdev.2006.08.002

Abstract Aims Power spectral analysis combined with a two-channel EEG system may be useful in management of newborn term infants at risk of hypoxic–ischaemic encephalopathy (HIE). This pilot study aimed to determine differences in the EEG power spectrum between normal term infants, infants who were at risk of but had not developed HIE, and infants who had developed HIE. Design Observational. Methods EEG recordings from normal term newborn infants and term infants at risk of HIE were analyzed using fast Fourier transforms. EEG total power (TP), TP variance, TP coefficient of variation (TP CV) and spectral edge frequency (SEF) were compared between three groups: control infants ( n = 15); at-risk infants who had not developed clinically diagnosed HIE ( n = 4); and at-risk infants who had developed HIE ( n = 7). Results Total power was similar in all groups. Variation of TP (variance and CV) was higher ( p < 0.05) in control infants than in infants at risk of HIE, regardless of whether they had developed HIE. SEF values were similar across all three groups. Conclusion Reduced variation of EEG power is a feature of infants at risk of HIE.