Adult Still's disease associated with cytomegalovirus infection

Abstract A 77-year-old woman was admitted to our hospital complaining of high fever. The physical examination on admission indicated no abnormality. Although several antibiotics were administered, the spiking high fever was not alleviated. Two weeks after admission a macular rash appeared, and a hig...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2007-04, Vol.13 (2), p.114-117
Main Authors: Izumikawa, Kinichi, Morinaga, Yoshitomo, Kondo, Akira, Hara, Kohei, Izumikawa, Koichi, Miyazaki, Yoshitsugu, Kohno, Shigeru, Igari, Narihiko, Akaboshi, Mana, Kawakami, Jun, Eguchi, Katsumi
Format: Article
Language:English
Subjects:
Adult
Aged
Antiviral Agents - therapeutic use
Cytomegalovirus
Cytomegalovirus - immunology
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - drug therapy
Female
Ferritins - blood
Fever - virology
Fever of Unknown origin (FUO)
Ganciclovir - therapeutic use
Hematology, Oncology and Palliative Medicine
Humans
Still's disease
Still's Disease, Adult-Onset - diagnosis
Still's Disease, Adult-Onset - virology
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Summary:Abstract A 77-year-old woman was admitted to our hospital complaining of high fever. The physical examination on admission indicated no abnormality. Although several antibiotics were administered, the spiking high fever was not alleviated. Two weeks after admission a macular rash appeared, and a high concentration of serum ferritin was observed. At this point, Still's disease was suspected, and the patient was referred to Nagasaki University Hospital. During the prescribed course of prednisolone, hepatic enzymes gradually increased to high titers accompanied by a positive test for cytomegalovirus (CMV) antigen. The CMV antigen disappeared after ganciclovir administration, and the concentration of serum ferritin decreased after steroid administration. In this report, we attempt to portray the relation between the pathogenesis of adult-onset Still's disease and the presence of CMV antigen.
ISSN:1341-321X
1437-7780
DOI:10.1007/s10156-007-0503-1