ETS transcription factors in endocrine systems

E26 transformation-specific (ETS) transcription factors have become increasingly recognized as key regulators of differentiation, hormone responses and tumorigenesis in endocrine organs and target tissues. The ETS family is highly diverse, consisting of both transcription activators and repressors t...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2007-05, Vol.18 (4), p.150-158
Main Authors: Gutierrez-Hartmann, Arthur, Duval, Dawn L, Bradford, Andrew P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Breast Neoplasms - metabolism
Endocrinology & Metabolism
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Mammary Glands, Human - metabolism
Models, Molecular
Pancreatic Neoplasms - metabolism
Pituitary Gland - metabolism
Prostate - metabolism
Proto-Oncogene Proteins c-ets - genetics
Proto-Oncogene Proteins c-ets - metabolism
Reproduction
Thyroid Neoplasms - metabolism
Vertebrates: endocrinology
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Summary:E26 transformation-specific (ETS) transcription factors have become increasingly recognized as key regulators of differentiation, hormone responses and tumorigenesis in endocrine organs and target tissues. The ETS family is highly diverse, consisting of both transcription activators and repressors that mediate growth factor signaling and regulate gene expression through combinatorial interactions with multiple protein partners on composite DNA elements. ETS proteins have a role in the endocrine system in establishing pituitary-specific gene expression, mammary gland development and cancers of the breast, prostate and reproductive organs.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2007.03.002