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ETS transcription factors in endocrine systems

E26 transformation-specific (ETS) transcription factors have become increasingly recognized as key regulators of differentiation, hormone responses and tumorigenesis in endocrine organs and target tissues. The ETS family is highly diverse, consisting of both transcription activators and repressors t...

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Published in:	Trends in endocrinology and metabolism 2007-05, Vol.18 (4), p.150-158
Main Authors:	Gutierrez-Hartmann, Arthur, Duval, Dawn L, Bradford, Andrew P
Format:	Article
Language:	English
Subjects:	Animals Biological and medical sciences Breast Neoplasms - metabolism Endocrinology & Metabolism Female Fundamental and applied biological sciences. Psychology Humans Male Mammary Glands, Human - metabolism Models, Molecular Pancreatic Neoplasms - metabolism Pituitary Gland - metabolism Prostate - metabolism Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism Reproduction Thyroid Neoplasms - metabolism Vertebrates: endocrinology
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description	E26 transformation-specific (ETS) transcription factors have become increasingly recognized as key regulators of differentiation, hormone responses and tumorigenesis in endocrine organs and target tissues. The ETS family is highly diverse, consisting of both transcription activators and repressors that mediate growth factor signaling and regulate gene expression through combinatorial interactions with multiple protein partners on composite DNA elements. ETS proteins have a role in the endocrine system in establishing pituitary-specific gene expression, mammary gland development and cancers of the breast, prostate and reproductive organs.
doi_str_mv	10.1016/j.tem.2007.03.002
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subjects	Animals Biological and medical sciences Breast Neoplasms - metabolism Endocrinology & Metabolism Female Fundamental and applied biological sciences. Psychology Humans Male Mammary Glands, Human - metabolism Models, Molecular Pancreatic Neoplasms - metabolism Pituitary Gland - metabolism Prostate - metabolism Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism Reproduction Thyroid Neoplasms - metabolism Vertebrates: endocrinology
title	ETS transcription factors in endocrine systems
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