New possibilities to study biliary tree and gallbladder: functional magnetic resonance cholangiography contrast-enhanced with mangafodipir trisodium (Mn DPDP)

Mangafodipir trisodium (Teslascan) is a hepatobiliary contrast agent that provides noninvasive opacification of the bile ducts. Using this contrast medium combined with a T1-weighted gradient echo enhanced sequence provides functional imaging of the bile ducts. Second-intention MRI was obtained afte...

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Bibliographic Details
Published in:Journal de radiologie 2007-04, Vol.88 (4), p.531-540
Main Authors: Laurent, V, Corby, S, Barbary, C, Kermarrec, E, Béot, S, Régent, D
Format: Article
Language:fre
Subjects:
Adult
Aged
Anastomosis, Surgical - adverse effects
Bile Duct Diseases - diagnosis
Bile Ducts, Intrahepatic - anatomy & histology
Biliary Tract Diseases - diagnosis
Choledochal Cyst - diagnosis
Contrast Media
Echo-Planar Imaging - methods
Edetic Acid - analogs & derivatives
Female
Gallbladder Diseases - diagnosis
Humans
Image Enhancement - methods
Imaging, Three-Dimensional - methods
Liver Transplantation - adverse effects
Living Donors
Magnetic Resonance Imaging - methods
Male
Manganese
Middle Aged
Postoperative Complications
Pyridoxal Phosphate - analogs & derivatives
Time Factors
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Summary:Mangafodipir trisodium (Teslascan) is a hepatobiliary contrast agent that provides noninvasive opacification of the bile ducts. Using this contrast medium combined with a T1-weighted gradient echo enhanced sequence provides functional imaging of the bile ducts. Second-intention MRI was obtained after the usual morphological study of the bile ducts using heavily T2-weighted sequences (SS-FSE Te eff long and SS FSE Te eff short). This method can detect many biliary duct anomalies: biliary leakage in the postoperative context, mapping of bile ducts and the gallbladder in the search for anatomical variants, analysis of biliodigestive or biliobiliary anastomoses, or a dynamic study of bile secretion and excretion. Opacification of the bile ducts has only been possible until now with invasive tests aggravated by a certain co-morbidity rate and their functional study using biliary scintigraphy limited by mediocre spatial resolution. This new possibility provides access not only to morphological imaging, but also to functional imaging with excellent spatial resolution.
ISSN:0221-0363
DOI:10.1016/S0221-0363(07)89852-0