Peritumoral brain edema in meningiomas: correlations between magnetic resonance imaging, angiography, and pathology

Abstract Background The purpose of this study was to evaluate the radiologic characteristics and pathology related to the formation of peritumoral edema in meningiomas. Methods Seventy-nine patients with meningioma were examined by MRI and cerebral angiography. The predictive factors possibly relate...

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Published in:Surgical neurology 2008-04, Vol.69 (4), p.350-355
Main Authors: Lee, Kyung-Jin, MD, Joo, Won-Il, MD, Rha, Hyung-Kyun, MD, Park, Hae-Kwan, MD, Chough, Jung-Ki, MD, Hong, Yong-Kil, MD, Park, Chun-Keun, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Brain Edema - etiology
Cerebral Angiography
Female
Humans
Magnetic resonance image
Magnetic Resonance Imaging
Male
Meningeal Neoplasms - complications
Meningeal Neoplasms - diagnostic imaging
Meningeal Neoplasms - pathology
Meningioma
Meningioma - complications
Meningioma - diagnostic imaging
Meningioma - pathology
Middle Aged
Neurology
Peritumoral edema
Pial blood supply
Retrospective Studies
Sex Factors
Surgery
Tumor Burden
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Summary:Abstract Background The purpose of this study was to evaluate the radiologic characteristics and pathology related to the formation of peritumoral edema in meningiomas. Methods Seventy-nine patients with meningioma were examined by MRI and cerebral angiography. The predictive factors possibly related to peritumoral edema, such as patient age, sex, tumor location, tumor size, peritumoral rim (CSF cleft), shape of tumor margin, signal intensity of tumor in T2WI, pial blood supply, and pathology, were evaluated. We defined the edema–tumor volume ratio as EI and used this index to evaluate peritumoral edema. Results Male sex ( P = .009), tumor size ( P = .026), signal intensity of tumor in T2WI ( P = .016), atypical and malignant tumor ( P = .004), and pial blood supply ( P = .001) correlated with peritumoral edema on univariate analyses. However, in multivariate analyses, pial blood supply was statistically significant as a factor for peritumoral edema in meningioma ( P = .029). Male sex ( P = .067, P < .1) and hyperintensity in T2WI ( P = .075, P < .1) might have statistical probability in peritumoral edema. Conclusions In our results, male sex, hyperintensity on T2WI, and pial blood supply were associated with peritumoral edema in meningioma that influence the clinical prognosis of patients.
ISSN:0090-3019
1879-3339
DOI:10.1016/j.surneu.2007.03.027