Effects of an NMDA-receptor antagonist MK-801 on an MMN-like response recorded in anesthetized rats

Abstract In the human brain, auditory sensory memory has been extensively studied using a well-defined component of event-related potential named the mismatch negativity (MMN). The MMN is generated in the auditory and frontal cortices in response to deviant stimuli. In monkeys, cortical N -methyl- d...

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Bibliographic Details
Published in:Brain research 2008-04, Vol.1203, p.97-102
Main Authors: Tikhonravov, Dmitry, Neuvonen, Tuomas, Pertovaara, Antti, Savioja, Kati, Ruusuvirta, Timo, Näätänen, Risto, Carlson, Synnöve
Format: Article
Language:English
Subjects:
Acoustic Stimulation - methods
Analysis of Variance
Anesthesia
Animals
Auditory Cortex - drug effects
Auditory Cortex - physiology
Biological and medical sciences
Contingent Negative Variation - drug effects
Dizocilpine Maleate - pharmacology
Dose-Response Relationship, Drug
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Electroencephalography
Excitatory Amino Acid Agonists - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
Fundamental and applied biological sciences. Psychology
Male
Mismatch negativity (MMN)
MK-801
N-Methylaspartate - pharmacology
Neurology
Oddball paradigm
Rat
Rats
Reaction Time - drug effects
Vertebrates: nervous system and sense organs
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Summary:Abstract In the human brain, auditory sensory memory has been extensively studied using a well-defined component of event-related potential named the mismatch negativity (MMN). The MMN is generated in the auditory and frontal cortices in response to deviant stimuli. In monkeys, cortical N -methyl- d -aspartate (NMDA) receptors have a central role in the generation of the MMN. MMN-like responses have also been recorded in other animals, including rats. The present study aimed at determining whether the MMN-like response in rats depends on an intact NMDA-receptor system. We recorded auditory evoked responses during an oddball paradigm epidurally in anesthetized rats that had received intraperitoneal injections of saline or an NMDA-receptor antagonist MK-801. An MMN-like response was recorded in the oddball paradigm in saline-treated rats. Further, this response was dose-dependently blocked by MK-801. These results suggest that the MMN-like response in rats depends on an intact NMDA-receptor system.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2008.02.006