The price of seizure control: Dynorphins in interictal and postictal psychosis

Abstract Postictal and interictal psychoses are relatively common complicating factors in the clinical course of epilepsy, yet their neurobiological substrates are poorly understood. Recent evidence shows that kappa opioid receptor (KOR) activation elicits anticonvulsant and psychotomimetic effects....

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Bibliographic Details
Published in:Psychiatry research 2007-05, Vol.151 (1), p.139-143
Main Authors: Bortolato, Marco, Solbrig, Marylou V
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - metabolism
Biological and medical sciences
Dynorphin
Dynorphins - metabolism
Epilepsy, Temporal Lobe - complications
Epilepsy, Temporal Lobe - physiopathology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampus - physiopathology
Humans
Interictal psychosis
Kappa opioid receptors
Kindling, Neurologic - physiology
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Postictal psychosis
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychotic Disorders - physiopathology
Receptors, Opioid, kappa - physiology
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Summary:Abstract Postictal and interictal psychoses are relatively common complicating factors in the clinical course of epilepsy, yet their neurobiological substrates are poorly understood. Recent evidence shows that kappa opioid receptor (KOR) activation elicits anticonvulsant and psychotomimetic effects. In view of this background, here we introduce the hypothesis that epilepsy-related psychoses may partially result from excessive hippocampal dynorphin release and kappa opioid receptor overstimulation aimed at seizure control.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2006.11.004