PTHrP increases transcriptional activity of the integrin subunit alpha5

Increasing evidence is emerging highlighting the role of parathyroid hormone-related protein (PTHrP) during metastasis by regulating cell adhesion. The current study demonstrated that modulation of PTHrP expression by PTHrP overexpression and small interfering RNA-induced silencing resulted in chang...

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Bibliographic Details
Published in:British journal of cancer 2007-05, Vol.96 (9), p.1394-1403
Main Authors: Anderson, J A, Grabowska, A M, Watson, S A
Format: Article
Language:English
Subjects:
Adenocarcinoma
Breast Neoplasms
Cell Line, Tumor
Colonic Neoplasms
Female
Flow Cytometry
Gene Expression Regulation, Neoplastic
Humans
Integrin alpha5 - genetics
Parathyroid Hormone-Related Protein - genetics
Parathyroid Hormone-Related Protein - physiology
Protein Subunits - genetics
Reverse Transcriptase Polymerase Chain Reaction
Transcription, Genetic
Transfection
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Summary:Increasing evidence is emerging highlighting the role of parathyroid hormone-related protein (PTHrP) during metastasis by regulating cell adhesion. The current study demonstrated that modulation of PTHrP expression by PTHrP overexpression and small interfering RNA-induced silencing resulted in changes in cell adhesion and integrin expression. RNA interference of endogenous PTHrP caused a significant reduction in cell adhesion of a breast cancer cell line to collagen type I, fibronectin and laminin (P
ISSN:0007-0920