Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex

Cell viability studies of HT29 colon cancer cells treated with the CO-releasing compound [Mn(CO)(3)(tpm)]PF(6) revealed a significant photoinduced cytotoxicity comparable to that of established agent 5-fluorouracil (5-FU), while controls kept in the dark were unaffected at up to 100 microM.

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Published in:Chemical communications (Cambridge, England) England), 2008-04 (15), p.1798-1800
Main Authors: Niesel, Johanna, Pinto, Antonio, Peindy N'Dongo, Harmel W, Merz, Klaus, Ott, Ingo, Gust, Ronald, Schatzschneider, Ulrich
Format: Article
Language:English
Subjects:
Carbon Monoxide - chemistry
Manganese - chemistry
Photochemistry
Pyrazoles - chemistry
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description Cell viability studies of HT29 colon cancer cells treated with the CO-releasing compound [Mn(CO)(3)(tpm)]PF(6) revealed a significant photoinduced cytotoxicity comparable to that of established agent 5-fluorouracil (5-FU), while controls kept in the dark were unaffected at up to 100 microM.
doi_str_mv 10.1039/b719075a
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source Royal Society of Chemistry
subjects Carbon Monoxide - chemistry
Manganese - chemistry
Photochemistry
Pyrazoles - chemistry
title Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex
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