Percutaneous management of chronic deep venous reflux: review of experimental work and early clinical experience with bioprosthetic valve

• Published in: Vascular medicine (London, England) England), 2008-02, Vol.13 (1), p.75-84
• Main Authors: Pavcnik, Dusan, Uchida, Barry, Kaufman, John, Hinds, Monica, Keller, Frederick S, Rösch, Josef
• Format: Article
• Language: English
• Subjects: Animals; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Bioprosthesis; Blood and lymphatic vessels; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation - instrumentation; Cardiology. Vascular system; Chronic Disease; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Humans; Lower Extremity - blood supply; Medical sciences; Prosthesis Design; Stents; Treatment Outcome; Veins - transplantation; Venous Insufficiency - surgery
• ISSN: 1358-863X; 1477-0377
• DOI: 10.1177/1358863X07083474

Abstract Lower extremity chronic deep venous insufficiency (CDVI) is common and remains a major health problem worldwide. Selected patients benefited from direct deep vein valve surgical repair or valve transplantation. A major limitation of this approach is that most of the patients are not candidates for these procedures due to obstructions or residual thrombus throughout the vein. The past 15 years have witnessed experimental efforts at catheter-based management of CDVI. This review describes the initial designs and experimental evolution of a mechanical and bioprosthetic venous valve that can be implanted by using a transcatheter technique. These valves consisted of single, double, or triple cusp leaflets made of synthetic or biological materials attached to a carrier or frame. All described devices for percutaneous transcatheter valve placement rely on some form of a vascular stent for valve attachment.