Comparison of Pharmacokinetics of Individual Teicoplanin Components in Patients

Teicoplanin is a glycopeptide antibiotic comprising six closely related major components whose activities against specific microbial species differ. In order to clarify the significance of monitoring these components separately for determining the therapeutic effectiveness of teicoplanin, we measure...

Full description

Saved in:
Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2007, Vol.30(5), pp.952-954
Main Authors: Hanada, Kazuhiko, Ikari, Shingo, Koukaki, Yukari, Utena, Ayako, Kimura, Toshimi, Hamano, Kunitoshi, Ariki, Hiromune, Masuhara, Keiso, Ogata, Hiroyasu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Chromatography, High Pressure Liquid
Female
Humans
Male
Middle Aged
pharmacokinetics
plasma protein binding
Pneumonia - drug therapy
Pneumonia - metabolism
Sepsis - drug therapy
Sepsis - metabolism
Teicoplanin - blood
Teicoplanin - chemistry
Teicoplanin - pharmacokinetics
Teicoplanin - therapeutic use
teicoplanin component
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Teicoplanin is a glycopeptide antibiotic comprising six closely related major components whose activities against specific microbial species differ. In order to clarify the significance of monitoring these components separately for determining the therapeutic effectiveness of teicoplanin, we measured the total and unbound concentrations of the main teicoplanin components in plasma and the unbound fractions in patients. Teicoplanin components in plasma were determined separately by high-performance liquid chromatography following a co-extractive clean-up procedure. The concentrations of unbound teicoplanin components were estimated after plasma ultrafiltration. The plasma concentrations of the main components of teicoplanin were strongly correlated with each other. The apparent elimination rate constants of total bound and unbound teicoplanin calculated by population pharmacokinetic parameters were almost same among the components. Furthermore, the mean population unbound clearance corrected by the unbound fraction was almost the same among the components. These results suggest that monitoring the individual components of teicoplanin has no clinical significance based on the pharmacokinetics of teicoplanin.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.30.952