Effects of Posttraining Damage to the Pedunculopontine Tegmental Nucleus on Conditioned Stimulus Transfer in Two-Way Active Avoidance in Rats

The effects of posttraining excitotoxic lesions of the pedunculopontine tegmental nucleus (PPTg) on two-way active avoidance after changing the conditioned stimulus (CS) used during prelesion training were examined. Prelesion training was carried out with either a tone or a light as the CS, and this...

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Bibliographic Details
Published in:Behavioral neuroscience 2007-04, Vol.121 (2), p.411-421
Main Authors: Homs-Ormo, Sandra, Torras-Garcia, Meritxell, Portell-Cortés, Isabel, Edo-Izquierdo, Sílvia, Morgado-Bernal, Ignacio, Coll-Andreu, Margalida
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Animal
Animal behavior
Animals
Avoidance Conditioning
Avoidance Learning - physiology
Behavioral psychophysiology
Biological and medical sciences
Body Weight - physiology
Brain
Conditioned Stimulus
Conditioning, Operant - physiology
Effects
Experiments
Fundamental and applied biological sciences. Psychology
Handling (Psychology)
Male
Pedunculopontine Tegmental Nucleus - physiology
Photic Stimulation
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
Rodents
Stereotaxic Techniques
Tegmentum
Transfer (Learning)
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Summary:The effects of posttraining excitotoxic lesions of the pedunculopontine tegmental nucleus (PPTg) on two-way active avoidance after changing the conditioned stimulus (CS) used during prelesion training were examined. Prelesion training was carried out with either a tone or a light as the CS, and this CS was changed during postlesion training. Replacing the tone with a light reduced the performance of control and lesioned rats, but the degree of reduction was higher in the latter. Replacing the light with a tone had slight detrimental effects in lesioned rats but not in controls. Thus, posttraining PPTg lesions slowed down the reacquisition of shuttle-box avoidance under conditions of CS transfer, an effect that may be attributable to disruption of attention and/or gating of sensory stimuli.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.121.2.411