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Simple clinical tests may predict severe oropharyngeal dysphagia in Parkinson's disease

Objective: To determine if simple screening tests can predict severe oropharyngeal dysphagia in subjects with Parkinson's disease. Methodology: Forty‐five subjects (26 females) of average age 75 (range: 65–94) who were classified as Modified Hoehn and Yahr stages 2 to 5 were enrolled. The prese...

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Published in:	Movement disorders 2007-04, Vol.22 (5), p.640-644
Main Authors:	Lam, Kuen, Kwai Yi Lam, Florence, Kwong Lau, Kwok, Kay Chan, Yiu, Yee Ling Kan, Elaine, Woo, Jean, Kee Wong, Fat, Ko, Andrew
Format:	Article
Language:	English
Subjects:	Aged Aged, 80 and over Biological and medical sciences Body Mass Index Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Deglutition Disorders - diagnosis dysphagia Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hong Kong Humans Male Mass Screening Medical sciences Nervous system (semeiology, syndromes) Neurologic Examination Neurology Parkinson Disease - diagnosis Parkinson's disease Prospective Studies Risk Factors screening simple tests
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container_title	Movement disorders
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creator	Lam, Kuen Kwai Yi Lam, Florence Kwong Lau, Kwok Kay Chan, Yiu Yee Ling Kan, Elaine Woo, Jean Kee Wong, Fat Ko, Andrew
description	Objective: To determine if simple screening tests can predict severe oropharyngeal dysphagia in subjects with Parkinson's disease. Methodology: Forty‐five subjects (26 females) of average age 75 (range: 65–94) who were classified as Modified Hoehn and Yahr stages 2 to 5 were enrolled. The presence of oropharyngeal dysphagia was assessed by a symptom questionnaire, 50 ml water swallowing test and videofluroscopic swallowing study. Results: Six of the subjects had severe oropharyngeal dysphagia in videofluroscopic swallowing study. Subsequent multivariate analysis showed that 3 factors could independently predict severe oropharyngeal dysphagia. These included higher Modified Hoehn and Yahr stage (P = 0.042), low Body mass index (P = 0.014), and increased difficulty in keeping food or drink in the mouth (P = 0.047). The regression model had a positive predictive power of 96% (sensitivity: 83.3%, specificity: 97.4%). Conclusion: A combination of 3 simple clinical parameters may be useful for screening for severe oropharyngeal dysphagia as shown radiologically in subjects with Parkinson's disease. © 2007 Movement Disorder Society
doi_str_mv	10.1002/mds.21362
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Methodology: Forty‐five subjects (26 females) of average age 75 (range: 65–94) who were classified as Modified Hoehn and Yahr stages 2 to 5 were enrolled. The presence of oropharyngeal dysphagia was assessed by a symptom questionnaire, 50 ml water swallowing test and videofluroscopic swallowing study. Results: Six of the subjects had severe oropharyngeal dysphagia in videofluroscopic swallowing study. Subsequent multivariate analysis showed that 3 factors could independently predict severe oropharyngeal dysphagia. These included higher Modified Hoehn and Yahr stage (P = 0.042), low Body mass index (P = 0.014), and increased difficulty in keeping food or drink in the mouth (P = 0.047). The regression model had a positive predictive power of 96% (sensitivity: 83.3%, specificity: 97.4%). Conclusion: A combination of 3 simple clinical parameters may be useful for screening for severe oropharyngeal dysphagia as shown radiologically in subjects with Parkinson's disease. © 2007 Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.21362</identifier><identifier>PMID: 17266075</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Body Mass Index ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Deglutition Disorders - diagnosis ; dysphagia ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hong Kong ; Humans ; Male ; Mass Screening ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurologic Examination ; Neurology ; Parkinson Disease - diagnosis ; Parkinson's disease ; Prospective Studies ; Risk Factors ; screening ; simple tests</subject><ispartof>Movement disorders, 2007-04, Vol.22 (5), p.640-644</ispartof><rights>Copyright © 2007 Movement Disorder Society</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4882-cb86a642b015f234230a7b65e9fa712a2a318854ce62bbccf6c022ebe4e469ed3</citedby><cites>FETCH-LOGICAL-c4882-cb86a642b015f234230a7b65e9fa712a2a318854ce62bbccf6c022ebe4e469ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18738632$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17266075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lam, Kuen</creatorcontrib><creatorcontrib>Kwai Yi Lam, Florence</creatorcontrib><creatorcontrib>Kwong Lau, Kwok</creatorcontrib><creatorcontrib>Kay Chan, Yiu</creatorcontrib><creatorcontrib>Yee Ling Kan, Elaine</creatorcontrib><creatorcontrib>Woo, Jean</creatorcontrib><creatorcontrib>Kee Wong, Fat</creatorcontrib><creatorcontrib>Ko, Andrew</creatorcontrib><title>Simple clinical tests may predict severe oropharyngeal dysphagia in Parkinson's disease</title><title>Movement disorders</title><addtitle>Mov. Disord</addtitle><description>Objective: To determine if simple screening tests can predict severe oropharyngeal dysphagia in subjects with Parkinson's disease. Methodology: Forty‐five subjects (26 females) of average age 75 (range: 65–94) who were classified as Modified Hoehn and Yahr stages 2 to 5 were enrolled. The presence of oropharyngeal dysphagia was assessed by a symptom questionnaire, 50 ml water swallowing test and videofluroscopic swallowing study. Results: Six of the subjects had severe oropharyngeal dysphagia in videofluroscopic swallowing study. Subsequent multivariate analysis showed that 3 factors could independently predict severe oropharyngeal dysphagia. These included higher Modified Hoehn and Yahr stage (P = 0.042), low Body mass index (P = 0.014), and increased difficulty in keeping food or drink in the mouth (P = 0.047). The regression model had a positive predictive power of 96% (sensitivity: 83.3%, specificity: 97.4%). Conclusion: A combination of 3 simple clinical parameters may be useful for screening for severe oropharyngeal dysphagia as shown radiologically in subjects with Parkinson's disease. © 2007 Movement Disorder Society</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Deglutition Disorders - diagnosis</subject><subject>dysphagia</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hong Kong</subject><subject>Humans</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurologic Examination</subject><subject>Neurology</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson's disease</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>screening</subject><subject>simple tests</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkU1vEzEQhi1ERUPhwB9AvgDisK2_7RwhQAoqBVRQJS6W1ztbDPuFJ6HNv69LAj0hTqORnnln_JiQR5wdcsbEUd_goeDSiDtkxrXklRPa3iUz5pyuJHd6n9xH_M4Y55qbe2SfW2EMs3pGzs9SP3VAY5eGFENHV4ArpH3Y0ClDk-KKIvyCDHTM4_Qt5M1wAQVrNli6ixRoGujHkH-kAcfhGdImIQSEB2SvDR3Cw109IF_evP68OK5OPizfLl6cVFE5J6pYOxOMEjXjuhVSCcmCrY2GeRssF0GEcr7TKoIRdR1jayITAmpQoMwcGnlAnm5zpzz-XJfbfZ8wQteFAcY1esuUdsqp_4KCczs3TBbw-RaMeUTM0Popp7483HPmb3T7otv_1l3Yx7vQdd1Dc0vu_BbgyQ4IWOy2OQwx4S3nrHRG3gQdbbnL1MHm3xv9-1dnf1ZX24mEK7j6O1F-whsrrfbnp0u_WL47_nr68pNn8hpw5aYa</recordid><startdate>20070415</startdate><enddate>20070415</enddate><creator>Lam, Kuen</creator><creator>Kwai Yi Lam, Florence</creator><creator>Kwong Lau, Kwok</creator><creator>Kay Chan, Yiu</creator><creator>Yee Ling Kan, Elaine</creator><creator>Woo, Jean</creator><creator>Kee Wong, Fat</creator><creator>Ko, Andrew</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20070415</creationdate><title>Simple clinical tests may predict severe oropharyngeal dysphagia in Parkinson's disease</title><author>Lam, Kuen ; Kwai Yi Lam, Florence ; Kwong Lau, Kwok ; Kay Chan, Yiu ; Yee Ling Kan, Elaine ; Woo, Jean ; Kee Wong, Fat ; Ko, Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4882-cb86a642b015f234230a7b65e9fa712a2a318854ce62bbccf6c022ebe4e469ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Deglutition Disorders - diagnosis</topic><topic>dysphagia</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hong Kong</topic><topic>Humans</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurologic Examination</topic><topic>Neurology</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson's disease</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>screening</topic><topic>simple tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lam, Kuen</creatorcontrib><creatorcontrib>Kwai Yi Lam, Florence</creatorcontrib><creatorcontrib>Kwong Lau, Kwok</creatorcontrib><creatorcontrib>Kay Chan, Yiu</creatorcontrib><creatorcontrib>Yee Ling Kan, Elaine</creatorcontrib><creatorcontrib>Woo, Jean</creatorcontrib><creatorcontrib>Kee Wong, Fat</creatorcontrib><creatorcontrib>Ko, Andrew</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lam, Kuen</au><au>Kwai Yi Lam, Florence</au><au>Kwong Lau, Kwok</au><au>Kay Chan, Yiu</au><au>Yee Ling Kan, Elaine</au><au>Woo, Jean</au><au>Kee Wong, Fat</au><au>Ko, Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simple clinical tests may predict severe oropharyngeal dysphagia in Parkinson's disease</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov. Disord</addtitle><date>2007-04-15</date><risdate>2007</risdate><volume>22</volume><issue>5</issue><spage>640</spage><epage>644</epage><pages>640-644</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>Objective: To determine if simple screening tests can predict severe oropharyngeal dysphagia in subjects with Parkinson's disease. Methodology: Forty‐five subjects (26 females) of average age 75 (range: 65–94) who were classified as Modified Hoehn and Yahr stages 2 to 5 were enrolled. The presence of oropharyngeal dysphagia was assessed by a symptom questionnaire, 50 ml water swallowing test and videofluroscopic swallowing study. Results: Six of the subjects had severe oropharyngeal dysphagia in videofluroscopic swallowing study. Subsequent multivariate analysis showed that 3 factors could independently predict severe oropharyngeal dysphagia. These included higher Modified Hoehn and Yahr stage (P = 0.042), low Body mass index (P = 0.014), and increased difficulty in keeping food or drink in the mouth (P = 0.047). The regression model had a positive predictive power of 96% (sensitivity: 83.3%, specificity: 97.4%). Conclusion: A combination of 3 simple clinical parameters may be useful for screening for severe oropharyngeal dysphagia as shown radiologically in subjects with Parkinson's disease. © 2007 Movement Disorder Society</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17266075</pmid><doi>10.1002/mds.21362</doi><tpages>5</tpages></addata></record>
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subjects	Aged Aged, 80 and over Biological and medical sciences Body Mass Index Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Deglutition Disorders - diagnosis dysphagia Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hong Kong Humans Male Mass Screening Medical sciences Nervous system (semeiology, syndromes) Neurologic Examination Neurology Parkinson Disease - diagnosis Parkinson's disease Prospective Studies Risk Factors screening simple tests
title	Simple clinical tests may predict severe oropharyngeal dysphagia in Parkinson's disease
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