Meclonazepam analogues as potential new antihelmintic agents

New analogues of the potent antihelmintic meclonazepam were prepared and evaluated against Schistosoma mansoni. The biological data suggests substitution at positions 2 and 4 of meclonazepam could provide promising analogues for prophylactic and therapeutic activity against S. mansoni. New analogues...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2008-04, Vol.18 (7), p.2333-2336
Main Authors: Mahajan, Aman, Kumar, Vipan, Mansour, Nuha R.N., Bickle, Quentin, Chibale, Kelly
Format: Article
Language:English
Subjects:
Animals
Anthelmintics - chemical synthesis
Anthelmintics - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Benzodiazepinones - chemical synthesis
Benzodiazepinones - pharmacology
Biological and medical sciences
Meclonazepam
Medical sciences
Models, Chemical
Pharmacology. Drug treatments
Schistosoma mansoni
Schistosoma mansoni - drug effects
Schistosomiasis
Stereoisomerism
Structure-Activity Relationship
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Summary:New analogues of the potent antihelmintic meclonazepam were prepared and evaluated against Schistosoma mansoni. The biological data suggests substitution at positions 2 and 4 of meclonazepam could provide promising analogues for prophylactic and therapeutic activity against S. mansoni. New analogues of the potent antihelmintic meclonazepam were prepared and evaluated against Schistosoma mansoni. The biological data suggests substitution at positions 2 and 4 of meclonazepam could provide promising analogues for prophylactic and therapeutic activity against S. mansoni.
ISSN:0960-894X
0968-0896
1464-3405
1464-3391
DOI:10.1016/j.bmcl.2008.02.077