Direct Cellular Responses to Platinum-Induced DNA Damage

The proteins involved in the cellular responses of replication, transcription, repair, and chromatin structure also mediate responses to platinum-damaged DNA. The communication of these proteins with each other which affect their roles in mediating anti-cancer activity of platinum-based drugs is rev...

Full description

Saved in:
Bibliographic Details
Published in:Chemical reviews 2007-05, Vol.107 (5), p.1387-1407
Main Authors: Jung, Yongwon, Lippard, Stephen J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Biochemistry
Cellular biology
DNA - drug effects
DNA - genetics
DNA - metabolism
DNA damage
DNA Damage - drug effects
DNA Repair - drug effects
DNA Repair - physiology
Humans
Neoplasms - genetics
Neoplasms - pathology
Platinum
Platinum - pharmacology
Proteins
Signal transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The proteins involved in the cellular responses of replication, transcription, repair, and chromatin structure also mediate responses to platinum-damaged DNA. The communication of these proteins with each other which affect their roles in mediating anti-cancer activity of platinum-based drugs is reviewed.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr068207j