Pharmacokinetics and physiological effects of two intravenous infusion rates of morphine in conscious dogs

This study examined the pharmacokinetics and physiologic effects of two infusions rates of morphine in conscious dogs. Five adult dogs were randomly studied at weekly intervals. An initial dose of either 0.3 or 0.6 mg/kg were each followed by infusions of 0.17 and 0.34 mg/kg/h. Plasma morphine conce...

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Published in:Journal of veterinary pharmacology and therapeutics 2007-06, Vol.30 (3), p.224-233
Main Authors: GUEDES, A.G.P, PAPICH, M.G, RUDE, E.P, RIDER, M.A
Format: Article
Language:English
Subjects:
analgesia
analgesic effect
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - blood
Analgesics, Opioid - pharmacokinetics
Animals
application rate
Behavior, Animal
clinical trials
Consciousness
Cross-Over Studies
dogs
Dogs - metabolism
dosage
drug therapy
Female
Infusions, Intravenous - veterinary
intravenous injection
morphine
Morphine - administration & dosage
Morphine - blood
Morphine - pharmacokinetics
Pain - prevention & control
Pain - veterinary
Pain Measurement - veterinary
pharmacokinetics
physiological response
veterinary drugs
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Summary:This study examined the pharmacokinetics and physiologic effects of two infusions rates of morphine in conscious dogs. Five adult dogs were randomly studied at weekly intervals. An initial dose of either 0.3 or 0.6 mg/kg were each followed by infusions of 0.17 and 0.34 mg/kg/h. Plasma morphine concentrations, physiological parameters, sedation and mechanical antinociception were evaluated during each infusion. Morphine was assayed by high pressure liquid chromatography (HPLC) with electrochemical coulometric detection and pharmacokinetic parameters were calculated. Data were fitted to a bi-compartment model with a rapid distribution (95% and body temperature decreased significantly during both infusions. No vomition or neuroexcitation occurred. Sedation and mechanical antinociception were both mild during the lower infusion rate, and mild to moderate during the higher infusion rate. In conclusion, morphine pharmacokinetics was not altered by increasing infusion rates, producing stable, long-lasting plasma concentrations.
ISSN:0140-7783
1365-2885
DOI:10.1111/j.1365-2885.2007.00849.x