Lung tissue mechanics predict lung hypoplasia in a rabbit model for congenital diaphragmatic hernia

Several animal models have been proposed to study the pathophysiology of congenital diaphragmatic hernia (CDH). Surgical induction of CDH in fetal rabbits during the pseudoglandular phase has been shown to induce severe pulmonary hypoplasia, but functional studies in this model are scarce. We aimed...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric pulmonology 2007-06, Vol.42 (6), p.505-512
Main Authors: Flemmer, Andreas W., Jani, Jacques C., Bergmann, Florian, Muensterer, Oliver J., Gallot, Denis, Hajek, Kerstin, Sugawara, Junichi, Till, Holger, Deprest, Jan A.
Format: Article
Language:English
Subjects:
Airway Resistance
Animals
Animals, Newborn
Biological and medical sciences
diaphragmatic hernia
Disease Models, Animal
elastance
Female
Fetus - pathology
General aspects
Hernia, Diaphragmatic - physiopathology
Hernias, Diaphragmatic, Congenital
hysteresivity
Lung - abnormalities
Lung - physiopathology
lung hypoplasia
Medical sciences
Pneumology
rabbit model
Rabbits
Respiratory Function Tests
Respiratory Mechanics - physiology
Severity of Illness Index
Total Lung Capacity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several animal models have been proposed to study the pathophysiology of congenital diaphragmatic hernia (CDH). Surgical induction of CDH in fetal rabbits during the pseudoglandular phase has been shown to induce severe pulmonary hypoplasia, but functional studies in this model are scarce. We aimed to measure neonatal pulmonary impedance and related it to the severity of lung hypoplasia. CDH was surgically created in rabbits at 23 days of gestation. Following cesarean delivery at term (31 days) pups were subjected to measurement of total lung capacity (TLC), lung to body weight ratio (LBWR) and lung impedance by forced oscillation technique (FOT). Airway resistance (Raw), tissue elastance (HL), tissue damping (GL), and hysteresivity (η) (GL/HL) were calculated from impedance data. Twelve CDH fetuses and 15 controls were available for final analysis. LBWR and TLC were significantly lower in the CDH group compared to gestational and age matched controls (P 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.20618