Epstein-barr virus-positive blastoid variant of mantle cell lymphoma in an adult with recurrent infectious mononucleosis-like symptoms : A case report

Epstein-Barr virus (EBV) is closely associated with several lymphomas, such as Burkitt lymphoma, natural killer/T-cell lymphoma, peripheral T-cell lymphoma, and Hodgkin's lymphoma; however, whether EBV is implicated in mantle cell lymphoma (MCL) has not been established. We report the case of a...

Full description

Saved in:
Bibliographic Details
Published in:International journal of hematology 2007-04, Vol.85 (3), p.219-222
Main Authors: HIGUCHI, Masakazu, MUTA, Tsuyoshi, KARUBE, Ken-Nosuke, ETO, Tetsuya, YAMANO, Yujiro, OHSHIMA, Koichi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Hematologic and hematopoietic diseases
Herpesvirus 4, Human - pathogenicity
Human viral diseases
Humans
Infectious diseases
Infectious Mononucleosis - pathology
Infectious Mononucleosis - virology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymph Nodes - pathology
Lymphoma, Mantle-Cell - virology
Male
Medical sciences
Middle Aged
Recurrence
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epstein-Barr virus (EBV) is closely associated with several lymphomas, such as Burkitt lymphoma, natural killer/T-cell lymphoma, peripheral T-cell lymphoma, and Hodgkin's lymphoma; however, whether EBV is implicated in mantle cell lymphoma (MCL) has not been established. We report the case of an adult with recurrent infectious mononucleosis (IM)-like symptoms who developed an EBV-positive blastoid variant of MCL. A 54-year-old Japanese man presented with fever, swelling of the oral mucosa and tongue, dispersed pulmonary infiltrations, systemic lymphadenopathy, and splenomegaly. He had a history of recurrent IM-like symptoms (prolonged fever and cervical lymphadenopathy) for at least 1 year. MCL was diagnosed by biopsy of the cervical lymph node. The anti-EBV antibody titer indicated a reactivation of chronic infection with this virus. EBV was detected in most of the lymphoma cells and in the peripheral blood. EBV might have played some role in the tumorigenesis of blastoid MCL.
ISSN:0925-5710
1865-3774
DOI:10.1532/IJH97.06178